Analysis of trabecular bone microstructure in osteoporotic femoral heads in human patients: in vivo study using multidetector row computed tomography.

• Material Type: 博士論文
• Title: Analysis of trabecular bone microstructure in osteoporotic femoral heads in human patients: in vivo study using multidetector row computed tomography.
• Author/Editor: Munemoto, Mitsuru; Kido, Akira; Sakamoto, Yoshihiro; Inoue, Kazuya; Yokoi, Kazuyuki; Shinohara, Yasushi; Tanaka, Yasuhito
• Author Heading: Munemoto, Mitsuru; Kido, Akira; Sakamoto, Yoshihiro; Inoue, Kazuya; Yokoi, Kazuyuki; Shinohara, Yasushi; Tanaka, Yasuhito
• Publication, Distribution, etc.: BioMed Central
• Publication Date: 2016-01
• Publication Date (W3CDTF): 2016-01
• Alternative Title: 骨粗鬆患者大腿頭における海綿微細構造解析 : MDCTを用いたin vivo研究
• Periodical title: BMC musculoskeletal disorders
• No. or year of volume/issue: 17
• Volume: 17
• Pages: Article No.13-
• ISSN (Periodical Title): ISSN : 1471-2474
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2016-07-08
• Dissertation Number: 乙第1378号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Trabecular structure; Microstructure; Femoral head; Osteoporosis
• Target Audience: 一般
• Note (General): type:Article; BACKGROUND: Lag screw position is very important in the treatment of intertrochanteric femoral fracture to prevent complications such as screw cut-out. Current studies recommend central or inferior placement of the lag screw on the anteroposterior radiograph, and central placement on the lateral radiographs. These reports are based on radiographic evaluation, but few studies have investigated the importance of bone quality at the site of lag screw placement. In this study, we used multidetector row computed tomography (MDCT) to perform in vivo evaluation of the bone microstructure of the femoral head in patients with intertrochanteric femoral fractures. METHODS: This study was approved by the Ethics Committee of Okanami General Hospital. MDCT images were obtained in our hospital from ten patients who had sustained intertrochanteric femoral fracture. Patients who needed computed tomography to confirm fracture morphology were included. We defined six areas as regions of interest (ROI): ROI 1-3 were defined as the femoral head apex area, and ROI 4-6 were defined as the femoral neck area. Trabecular microstructure parameters, including mean bone volume to total volume (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and structure model index (SMI), were evaluated with bone analysis software (TRI/3D-BON). Statistical analyses were performed using EZR software; each parameter among the ROIs was statistically evaluated by analysis of variance (ANOVA) and Tukey's test. Statistical significance was established at p < 0.05. RESULTS: In the apical area, all parameters indicated that ROI 1 (superior) had the highest bone quality and ROI 2 (central) was higher in bone quality than ROI 3 (inferior). In the femoral neck, all parameters indicated that bone quality was significantly greater in ROI 6 (inferior) than ROI 5 (central). DISCUSSION AND CONCLUSIONS: We could evaluate bone quality with clinical MDCT in vivo. Bone quality in the central area of the femoral head apical was greater than in the inferior area, and bone quality in the inferior area of the femoral neck was greater than in the central area. Recognizing which area of femoral head has greater bone quality may lead to a better clinical result in treating intertrochanteric femoral fracture.; 博士（医学）・乙第1378号・平成28年7月8日; © Munemoto et al. 2016 Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.; identifier:BMC musculoskeletal disorders Vol.17 Article No.13 (2016 Jan); identifier:14712474; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3257; identifier:BMC musculoskeletal disorders, 17: Article No.13
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3257/1/01_%e4%b9%991378%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3257/2/02_%e4%b9%991378%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3257/3/03_%e4%b9%991378%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/s12891-015-0848-z
• Periodical Title (NCID): AA12035278; https://ci.nii.ac.jp/ncid/AA12035278
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU