Structures Showing Negative Correlations of Signal Intensity with Postnatal Age on T1-weighted Imaging of the Brain of Newborns and Infants.

• Material Type: 博士論文
• Title: Structures Showing Negative Correlations of Signal Intensity with Postnatal Age on T1-weighted Imaging of the Brain of Newborns and Infants.
• Author/Editor: Hori, Saeka; Taoka, Toshiaki; Ochi, Tomoko; Miyasaka, Toshiteru; Sakamoto, Masahiko; Takayama, Katsutoshi; Wada, Takeshi; Myochin, Kaoru; Takahashi, Yukihiro; Kichikawa, Kimihiko
• Author Heading: Hori, Saeka; Taoka, Toshiaki; Ochi, Tomoko; Miyasaka, Toshiteru; Sakamoto, Masahiko; Takayama, Katsutoshi; Wada, Takeshi; Myochin, Kaoru; Takahashi, Yukihiro; Kichikawa, Kimihiko
• Publication, Distribution, etc.: 日本磁気共鳴医学会(Japan Society of Magnetic Resonance in Medicine)
• Publication Date: 2017-02-16
• Publication Date (W3CDTF): 2017-02-16
• Alternative Title: T1強調像での信号強度が出生後日数と負の相関性を示す新生児・乳児期の脳構造
• Periodical title: Magnetic resonance in medical sciences
• No. or year of volume/issue: 16 4
• Volume: 16
• Issue: 4
• Pages: 325-331
• ISSN (Periodical Title): ISSN : 1347-3182
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2017-06-28
• Dissertation Number: 乙第1405号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: newborn; brain; magnetic resonance imaging; T1-weighted images; development
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: Although the neonatal and infantile brain typically shows sequential T1 shortening according to gestational age as a result of myelination, several structures do not follow this rule. We evaluated the relationship between the signal intensity of various structures in the neonatal and infantile brain on T1-weighted imaging (T1WI) and either postnatal or gestational age. Materials and Methods: We examined magnetic resonance images from 120 newborns and infants without any abnormalities in the central nervous system. Written informed consent was obtained from all parents and the institutional review board approved the study. Gestational age at examination ranged from 35 weeks, 3 days to 46 weeks, 6 days, and postnatal age ranged from 7 days to 127 days. Signal intensity on T1WI was evaluated on a scale from Grade 1 (indistinguishable from surrounding structures) to Grade 4 (higher than cortex and close to fat). We evaluated relationships between the T1 signal grades of various structures in the neonatal brain and postnatal or gestational age using Spearman’s correlation analysis. Results: Significant positive correlations were identified between T1 signal grade and gestational age in the pyramidal tract (P < 0.001). Conversely, significant negative correlations were evident between T1 signal grade and postnatal age (P < 0.001), in structures including the stria medullaris thalami, fornix cerebellar vermis, dentate nucleus and anterior pituitary gland. Conclusion: Significant negative correlations exist between signal intensity on T1WI and postnatal age in some structures of the neonatal and infantile brain. Some mechanisms other than myelination might play roles in the course of signal appearance.; 博士（医学）・乙第1405号・平成29年6月28日; Copyright © 2017 by Japanese Society for Magnetic Resonance in Medicine : This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License(https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja).; identifier:Magnetic resonance in medical sciences Vol.16 No.4 p.325-331 (2017); identifier:13473182; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3351; identifier:Magnetic resonance in medical sciences, 16(4): 325-331
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2463/mrms.mp.2015-0168
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3351/1/01%e4%b9%991405%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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