Relationship between frequency spectrum of heart rate variability and autonomic nervous activities during sleep in newborns.

• Material Type: 博士論文
• Title: Relationship between frequency spectrum of heart rate variability and autonomic nervous activities during sleep in newborns.
• Author/Editor: Takatani, Tsunenori; Takahashi, Yukihiro; Yoshida, Ryota; Imai, Ryuko; Uchiike, Takao; Yamazaki, Masaharu; Shima, Midori; Nishikubo, Toshiya; Ikada, Yoshito; Fujimoto, Shinichi
• Author Heading: Takatani, Tsunenori; Takahashi, Yukihiro; Yoshida, Ryota; Imai, Ryuko; Uchiike, Takao; Yamazaki, Masaharu; Shima, Midori; Nishikubo, Toshiya; Ikada, Yoshito; Fujimoto, Shinichi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-03
• Publication Date (W3CDTF): 2018-03
• Alternative Title: 新生児の睡眠中の心拍変動周波数スペクトルと自律神経活動の関係
• Periodical title: Brain and development
• No. or year of volume/issue: 40 3
• Volume: 40
• Issue: 3
• Pages: 165-171
• ISSN (Periodical Title): ISSN : 0387-7604
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-03-15
• Dissertation Number: 乙第1418号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: EEG; Autonomic nervous system; Neonatal sleep; Heart rate variability
• Target Audience: 一般
• Note (General): type:Thesis; INTRODUCTION: We analyzed the frequency spectrum of two neonatal sleep stages, namely active sleep and quiet sleep, and the relationship between these sleep stages and autonomic nervous activity in 74 newborns and 16 adults as a comparison. METHOD: Active and quiet sleep were differentiated by electroencephalogram (EEG) patterns, eye movements, and respiratory wave patterns; autonomic activity was analyzed using the RR interval of simultaneously recorded electrocardiogram (ECG) signals. Power values (LFa, absolute low frequency; HFa, absolute high frequency), LFa/HFa ratio, and the values of LFn (normalized low frequency) and HFn (normalized high frequency) were obtained. Synchronicity between the power value of HFa and the LFa/HFa ratio during active and quiet sleep was also examined by a new method of chronological demonstration of the power values of HFa and LFa/HFa. RESULTS: We found that LFa, HFa and the LFa/HFa ratio during active sleep were significantly higher than those during quiet sleep in newborns; in adults, on the other hand, the LFa/HFa ratio during rapid eye movement (REM) sleep, considered as active sleep, was significantly higher than that during non-REM sleep, considered as quiet sleep, and HFa values during REM sleep were significantly lower than those during non-REM sleep. LFn during quiet sleep in newborns was significantly lower than that during active sleep. Conversely, HFn during quiet sleep was significantly higher than that during active sleep. Analysis of the four classes of gestational age groups at birth indicated that autonomic nervous activity in a few preterm newborns did not reach the level seen in full-term newborns. Furthermore, the power value of HFa and the LFa/HFa ratio exhibited reverse synchronicity. CONCLUSION: These results indicate that the autonomic patterns in active and quiet sleep of newborns are different from those in REM and non-REM sleep of adults and may be develop to the autonomic patterns in adults, and that parasympathetic activity is dominant during quiet sleep as compared to active sleep from the results of LFn and HFn in newborns. In addition, in some preterm infants, delayed development of the autonomic nervous system can be determined by classifying the autonomic nervous activity pattern of sleep stages.; 博士（医学）・乙第1418号・平成30年3月15日; © 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.; identifier:Brain and development Vol.40 No.3 p.165-171 (2018 Mar); identifier:03877604; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3434; identifier:Brain and development, 40(3): 165-171
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3434/1/01%e4%b9%991418%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3434/2/02%e4%b9%991418%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3434/3/03%e4%b9%991418%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.braindev.2017.09.003
• Periodical Title (NCID): AA00111153; https://ci.nii.ac.jp/ncid/AA00111153
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU