Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial.

• Material Type: 博士論文
• Title: Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial.
• Author/Editor: Morimoto, Tsubasa; Matsuda, Yasuhiro; Matsuoka, Kiwamu; Yasuno, Fumihiko; Ikebuchi, Emi; Kameda, Hiroyuki; Taoka, Toshiaki; Miyasaka, Toshiteru; Kichikawa, Kimihiko; Kishimoto, Toshifumi
• Author Heading: Morimoto, Tsubasa; Matsuda, Yasuhiro; Matsuoka, Kiwamu; Yasuno, Fumihiko; Ikebuchi, Emi; Kameda, Hiroyuki; Taoka, Toshiaki; Miyasaka, Toshiteru; Kichikawa, Kimihiko; Kishimoto, Toshifumi
• Publication, Distribution, etc.: BioMed Central
• Publication Date: 2018-03-27
• Publication Date (W3CDTF): 2018-03-27
• Alternative Title: コンピュータを用いた認知矯正療法は、統合失調症患者の海馬容積を増大する：ランダム化比較対照試験
• Periodical title: BMC psychiatry Vol. No. (2018 Mar)
• No. or year of volume/issue: 18 1
• Volume: 18
• Issue: 1
• Pages: Article No.83-
• ISSN (Periodical Title): ISSN : 1471-244X
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-09-26
• Dissertation Number: 甲第689号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Cognitive remediation; Rehabilitation; Structural neuroimaging; Hippocampus; Schizophrenia; Jcores
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND:Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects. We investigated these effects, as well as the association between changes in cortical volume and neurocognitive performance. METHOD:Between August 2013 and September 2016, we performed a randomized controlled study comprising a CRT group (16 individuals) and a treatment-as-usual (TAU) group (15 individuals) of patients with schizophrenia. CRT participants engaged in twice-weekly computer-assisted CRT sessions and weekly group meetings for 12 weeks. T1-weighted magnetic resonance imaging was performed before and after the intervention period, and whole-brain voxel-based morphometric analysis was used to detect significant cortical gray matter volume changes. We also assessed the correlation between cortical volume changes and CRT-derived neurocognitive improvements. RESULTS:The CRT group exhibited significantly greater improvements than the TAU group in verbal fluency (P = 0.012) and global cognitive scores (P = 0.049). The CRT group also exhibited significantly greater increases in right hippocampal volume than the TAU group (P < 0.001). Changes in verbal fluency scores and right hippocampal volumes were positively correlated (r = 0.53, P = 0.001). CONCLUSION:We found that CRT significantly increased right hippocampal volumes and that these enhancements were positively correlated with changes in verbal fluency scores. Our results indicate that CRT induces cognitive improvement through hippocampal plasticity. TRIAL REGISTRATION:Registration number:UMIN000026146 , 2017/02/15, retrospectively registered.; 博士（医学）・甲第689号・平成30年9月26日; This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.; identifier:BMC psychiatry Vol.18 No.1 Article No.83 (2018 Mar); identifier:1471244X; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3497; identifier:BMC psychiatry Vol. No. (2018 Mar), 18(1): Article No.83
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/s12888-018-1667-1
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3497/1/01%e7%94%b2689%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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