Influence of Underlying Diseases and Age on the Association between Obesity and All-Cause Mortality in Post-Middle Age.

• Material Type: 博士論文
• Title: Influence of Underlying Diseases and Age on the Association between Obesity and All-Cause Mortality in Post-Middle Age.
• Author/Editor: Yoshimoto, Kazuki; Noda, Tatsuya; Imamura, Tomoaki
• Author Heading: Yoshimoto, Kazuki; Noda, Tatsuya; Imamura, Tomoaki
• Publication, Distribution, etc.: Scientific Research Publishing Inc.
• Publication Date: 2018-09-11
• Publication Date (W3CDTF): 2018-09-11
• Alternative Title: 肥満と全原因死亡率との関連に基礎疾患と年齢が及ぼす影響
• Periodical title: Health
• No. or year of volume/issue: 10 9
• Volume: 10
• Issue: 9
• Pages: 1171-1184
• ISSN (Periodical Title): ISSN : 1949-4998
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-11-30
• Dissertation Number: 甲第691号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Underlying Diseases; Obesity; All-Cause Mortality; Post-Middle Age
• Target Audience: 一般
• Note (General): type:Thesis; Background: Studies on the association between obesity and all-cause mortality have found that the degree of obesity is directly proportional to all-cause mortality. In contrast, there have been studies indicating that obese people with underlying diseases have a higher survival rate. We hypothesized that age and underlying diseases lead to such contrasting results. Therefore, we conducted a study to clarify the influence of post-middle age obesity and underlying diseases on all-cause mortality. Methods: This study used data from longitudinal studies in the United States, which conducted follow-up for 19 years on 33,708 participants in different age groups: ≥45, 45 - 64, and ≥65 years. Hazard ratio (HR) was determined using the Cox proportional hazards model to analyze a group consisting of all participants, a group of those with underlying diseases, and a group of those without underlying diseases, considering age, gender, education history, marital status, household income, smoking history, and BMI category as covariates. Results: In the group aged ≥65 without underlying diseases, HR was almost 1 in those with BMI 25 - <30, 30 - <35, and BMI > 35 kg/m2. Further, HR was higher in the 45 - 64 age group without underlying diseases if BMI was >35 kg/m2. However, HR was approximately 1 in the ≥65 age group. Conclusions: The study revealed that among individuals aged ≥65 years without underlying diseases, there was no association between obesity and all-cause mortality. Among individuals without underlying diseases, HR was higher in the 45 - 64 age group with BMI > 35 kg/m2 but was approximately 1 among those aged ≥65 years. Therefore, an interaction based on age was detected. These findings may lead to recommendations regarding the need to modify the advice and education provided to obese individuals in different age groups.; 博士（医学）・甲第691号・平成30年11月30日; Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/; identifier:Health Vol.10 No.9 p.1171-1184 (2018 Sep); identifier:19494998; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3502; identifier:Health, 10(9): 1171-1184
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.4236/health.2018.109089
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3502/1/01%e7%94%b2691%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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