Epidermal growth factor receptor inhibitors selectively inhibit the expressions of human β-defensins induced by Staphylococcus epidermidis.

• Material Type: 博士論文
• Title: Epidermal growth factor receptor inhibitors selectively inhibit the expressions of human β-defensins induced by Staphylococcus epidermidis.
• Author/Editor: Park, Kio; Ommori, Rie; Imoto, Kyoko; Asada, Hideo
• Author Heading: Park, Kio; Ommori, Rie; Imoto, Kyoko; Asada, Hideo
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2014-08
• Publication Date (W3CDTF): 2014-08
• Alternative Title: EGFR阻害薬は表皮ブドウ球菌によるβディフェンシンの発現を選択的に抑制する
• Periodical title: Journal of dermatological science
• No. or year of volume/issue: 75 2
• Volume: 75
• Issue: 2
• Pages: 94-99
• ISSN (Periodical Title): ISSN : 0923-1811
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-11-30
• Dissertation Number: 乙第1422号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Erlotinib; Gefitinib; Human β-defensins
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND: Epidermal growth factor receptor inhibitors (EGFRIs) have developed as one of the potential treatment options for various kinds of cancers. Although a variety of dermatological adverse reactions such as follicular acneiform eruptions is commonly encountered, the mechanism of the reactions remains unclear. OBJECTIVES: We investigated the effects of EGFRIs on the expression of human β-defensins against staphylococci to study the pathomechanism of cutaneous adverse reactions caused by EGFRIs. METHODS: We investigated the expressions of human β-defensins 1, 2, and 3 (hBD1, 2, and 3) from staphylococci-stimulated normal human epidermal keratinocytes (NHEKs) cultured with or without the effects of two EGFRIs, gefitinib and erlotinib. We stimulated NHEKs with the supernatant of Staphylococcus aureus (S. aureus) and S. epidermidis and the live staphylococci. We measured hBDs in the culture supernatants of NHEKs by enzyme-linked immunosorbent assay (ELISA). RESULTS: EGFRIs did not suppress the expressions of hBD1 and 3 induced by S. aureus. In contrast, EGFRIs suppressed the expressions of hBD2 and 3 induced by S. epidermidis. CONCLUSION: EGFRIs may cause cutaneous adverse effects through selectively perturbing innate immune responses induced by commensal and pathogenic bacteria.; 博士（医学）・乙第1423号・平成30年11月30日; Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.; identifier:Journal of dermatological science Vol.75 No.2 p.94-99 (2014 Aug); identifier:09231811; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3506; identifier:Journal of dermatological science, 75(2): 94-99
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.jdermsci.2014.04.011
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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