Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis.

• Material Type: 博士論文
• Title: Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis.
• Author/Editor: Ishida, Yukako; Kido, Akira; Akahane, Manabu; Kishi, Shingo; Tsukamoto, Shinji; Fujii, Hiromasa; Honoki, Kanya; Tanaka, Yasuhito
• Author Heading: Ishida, Yukako; Kido, Akira; Akahane, Manabu; Kishi, Shingo; Tsukamoto, Shinji; Fujii, Hiromasa; Honoki, Kanya; Tanaka, Yasuhito
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-09
• Publication Date (W3CDTF): 2018-09
• Alternative Title: ヒト間葉系幹細胞はエオタキシン3/CCR3経路を介して前立腺癌細胞の浸潤能を増加させる
• Periodical title: Pathology, research and practice
• No. or year of volume/issue: 214 9
• Volume: 214
• Issue: 9
• Pages: 1297-1302
• ISSN (Periodical Title): ISSN : 0344-0338
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-11-30
• Dissertation Number: 乙第1424号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Mesenchymal stem cells; Cancer microenvironment; Eotaxin-3; CCR3; Homing chemokines
• Target Audience: 一般
• Note (General): type:Thesis; This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. Among several homing chemokines, an antibody array revealed that expression of eotaxin-3 (but not eotxin-1 and -2) was highly enhanced in MSCs treated with PC-3-conditioned medium. A gene expression array showed significantly increased expression of CCR3, a receptor of eotaxin-3, in PC-3. In a matrigel invasion assay, interferon-gamma, a specific inhibitor of eotaxin-related homing, significantly reduced the transmigration of PC-3 cells, under co-cultured condition with MSCs, in a dose-dependent manner (P < 0.05). Consistent with these results, anti-CCR3 antibody successfully reduced PC-3 migration under the co-cultured condition. These findings suggest that MSCs to modulation of the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis.; 博士（医学）・乙第1424号・平成30年11月30日; © 2018 Elsevier GmbH. All rights reserved.; identifier:Pathology, research and practice Vol.214 No.9 p.1297-1302 (2018 Sep); identifier:03440338; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3507; identifier:Pathology, research and practice, 214(9): 1297-1302
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.prp.2018.06.012
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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