NGF and BDNF expression in mouse DRG after spared nerve injury.

• Material Type: 博士論文
• Title: NGF and BDNF expression in mouse DRG after spared nerve injury.
• Author/Editor: Terada, Yuki; Morita-Takemura, Shoko; Isonishi, Ayami; Tanaka, Tatsuhide; Okuda, Hiroshi; Tatsumi, Kouko; Shinjo, Takeaki; Kawaguchi, Masahiko; Wanaka, Akio
• Author Heading: Terada, Yuki; Morita-Takemura, Shoko; Isonishi, Ayami; Tanaka, Tatsuhide; Okuda, Hiroshi; Tatsumi, Kouko; Shinjo, Takeaki; Kawaguchi, Masahiko; Wanaka, Akio
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-11-01
• Publication Date (W3CDTF): 2018-11-01
• Alternative Title: Spared nerve injury後のマウス後根神経節におけるNGFとBDNFの発現
• Periodical title: Neuroscience letters
• No. or year of volume/issue: 686
• Volume: 686
• Pages: 67-73
• ISSN (Periodical Title): ISSN : 0304-3940
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-03-15
• Dissertation Number: 甲第698号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: BDNF; Dorsal root ganglion; NGF; Neuropathic pain; Spared nerve injury
• Target Audience: 一般
• Note (General): type:Thesis; Neuropathic pain is initiated by a primary lesion in the peripheral nervous system and spoils quality of life. Neurotrophins play important roles in the development and transmission of neuropathic pain. There are conflicting reports that the dorsal root ganglion (DRG) in an injured nerve contribute to neuropathic pain, whereas several studies have highlighted the important contribution of the DRG in a non-injured nerve. Clarifying the role of neurotrophins in neuropathic pain is problematic because we cannot distinguish injured and intact neurons in most peripheral nerve injury models. In the present study, to elicit neuropathic pain, we used the spared nerve injury (SNI) model, in which injured DRG neurons are distinguishable from intact ones, and mechanical allodynia develops in the intact sural nerve skin territory. We examined nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model mice. NGF and BDNF levels increased in the injured L3 DRG, while NGF decreased in the intact L5 DRG. These data offer a new point of view on the role of these neurotrophins in neuropathic pain induced by peripheral nerve injury.; 博士（医学）・甲第698号・平成31年3月15日; © 2018 Elsevier B.V. All rights reserved.; identifier:Neuroscience letters Vol.686 p.67-73 (2018 Nov); identifier:03043940; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3546; identifier:Neuroscience letters, 686: 67-73
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.neulet.2018.08.051
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3546/1/01%e7%94%b2698%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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