Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study.

• Material Type: 博士論文
• Title: Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study.
• Author/Editor: Nakano, Tomoya; Onoue, Kenji; Nakada, Yasuki; Nakagawa, Hitoshi; Kumazawa, Takuya; Ueda, Tomoya; Nishida, Taku; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Kawakami, Rika; Horii, Manabu; Okura, Hiroyuki; Uemura, Shiro; Hatakeyama, Kinta; Sakaguchi, Yasuhiro; Saito, Yoshihiko
• Author Heading: Nakano, Tomoya; Onoue, Kenji; Nakada, Yasuki; Nakagawa, Hitoshi; Kumazawa, Takuya; Ueda, Tomoya; Nishida, Taku; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Kawakami, Rika; Horii, Manabu; Okura, Hiroyuki; Uemura, Shiro; Hatakeyama, Kinta; Sakaguchi, Yasuhiro; Saito, Yoshihiko
• Publication, Distribution, etc.: Springer Nature Publishing AG
• Publication Date: 2018-08-24
• Publication Date (W3CDTF): 2018-08-24
• Alternative Title: 急性期たこつぼ症候群症例の心内膜心筋生検を用いた左室心筋細胞におけるβ-アドレナリン受容体シグナル動態の検討
• Periodical title: Scientific reports
• No. or year of volume/issue: 8 1
• Volume: 8
• Issue: 1
• Pages: Article No.12731-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-03-15
• Dissertation Number: 甲第701号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; Accumulating evidence indicates alteration of the β-adrenoceptor (AR), such as desensitization and subtype switching of its coupling G protein, plays a role in the protection against catecholamine toxicity in heart failure. However, in human takotsubo syndrome (TTS), which is associated with a surge of circulating catecholamine in the acute phase, there is no histologic evidence of β-AR alteration. The purpose of this study was to investigate the involvement of alteration of β-AR signaling in the mechanism of TTS development. Left ventricular (LV) biopsied samples from 26 patients with TTS, 19 with normal LV function, and 26 with dilated cardiomyopathy (DCM) were studied. G protein-coupled receptor kinase 2 (GRK2) and β-arrestin2, which initiate the alteration of β-AR signaling, were more abundantly expressed in the myocardium in acute-phase TTS than in those of DCM and normal control as indicated by immunohistochemistry. The percentage of cardiomyocytes that showed positive membrane staining for GRK2 and β-arrestin2 was also significantly higher in acute-phase TTS. Sequential biopsies in the recovery-phase for two patients with TTS revealed that membrane expression of GRK2 and β-arrestin2 faded over time. This study provided the first histologic evidence of the involvement of alteration of β-ARs in the development of TTS.; 博士（医学）・甲第701号・平成31年3月15日; © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.; © 2018 Springer Nature Publishing AG; identifier:Scientific reports Vol.8 No.1 Article No.12731 (2018 Aug); identifier:20452322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3549; identifier:Scientific reports, 8(1): Article No.12731
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3549/1/01%e7%94%b2701%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3549/2/02%e7%94%b2701%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3549/3/03%e7%94%b2701%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-018-31034-z
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU