Childhood cancer incidence and survival in Japan and England: A population-based study (1993-2010).

• Material Type: 博士論文
• Title: Childhood cancer incidence and survival in Japan and England: A population-based study (1993-2010).
• Author/Editor: Nakata, Kayo; Ito, Yuki; Magadi, Winnie; Bonaventure, Audrey; Stiller, Charles A.; Katanoda, Kota; Matsuda, Tomohiro; Miyashiro, Isao; Pritchard-Jones, Kathy; Rachet, Bernard
• Author Heading: Nakata, Kayo; Ito, Yuki; Magadi, Winnie; Bonaventure, Audrey; Stiller, Charles A.; Katanoda, Kota; Matsuda, Tomohiro; Miyashiro, Isao; Pritchard-Jones, Kathy; Rachet, Bernard
• Publication, Distribution, etc.: John Wiley & Sons, Inc.
• Publication Date: 2018-02
• Publication Date (W3CDTF): 2018-02
• Alternative Title: がん登録データを用いた、小児がんの罹患率・死亡率の日英比較（1993-2010年）
• Periodical title: Cancer science
• No. or year of volume/issue: 109 2
• Volume: 109
• Issue: 2
• Pages: 422-434
• ISSN (Periodical Title): ISSN : 1347-9032
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-03-15
• Dissertation Number: 乙第1425号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: cancer registry data; childhood cancer; childhood cancer incidence and survival; epidemiology; population-based study
• Target Audience: 一般
• Note (General): type:Thesis; The present study aimed to compare cancer incidence and trends in survival for children diagnosed in Japan and England, using population-based cancer registry data. The analysis was based on 5192 children with cancer (age 0-14 years) from 6 prefectural cancer registries in Japan and 21 295 children diagnosed in England during 1993-2010. Differences in incidence rates between the 2 countries were measured with Poisson regression models. Overall survival was estimated using the Kaplan-Meier method. Incidence rates for Hodgkin lymphoma, renal tumors and Ewing sarcomas in England were more than twice as high as those in Japan. Incidence of germ cell tumors, hepatic tumors, neuroblastoma and acute myeloid leukemia (AML) was higher in Japan than in England. Incidence of all cancers combined decreased in Japan throughout the period 1993 to 2010, which was mainly explained by a decrease in registration of neuroblastoma in infants. For many cancers, 5-year survival improved in both countries. The improvement in survival in chronic myeloid leukemia (CML) was particularly dramatic in both countries. However, 5-year survival remained less than 80% in 2005-2008 in both countries for AML, brain tumors, soft tissue sarcomas, malignant bone tumors and neuroblastoma (age 1-14 years). There were significant differences in incidence of several cancers between countries, suggesting variation in genetic susceptibility and possibly environmental factors. The decrease in incidence for all cancers combined in Japan was related to the cessation of the national screening program for neuroblastoma. The large improvement in survival in CML coincided with the introduction of effective therapy (imatinib).; 博士（医学）・乙第1425号・平成31年3月15日; © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.; This is an open access article under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.; identifier:Cancer science Vol.109 No.2 p.422-434 (2018 Feb); identifier:13479032; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3557; identifier:Cancer science, 109(2): 422-434
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1111/cas.13457
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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