Plaque modification of severely calcified coronary lesions by scoring balloon angioplasty using Lacrosse non-slip element: insights from an optical coherence tomography evaluation.

• Material Type: 博士論文
• Title: Plaque modification of severely calcified coronary lesions by scoring balloon angioplasty using Lacrosse non-slip element: insights from an optical coherence tomography evaluation.
• Author/Editor: Sugawara, Yu; Ueda, Tomoya; Soeda, Tsunenari; Watanabe, Makoto; Okura, Hiroyuki; Saito, Yoshihiko
• Author Heading: Sugawara, Yu; Ueda, Tomoya; Soeda, Tsunenari; Watanabe, Makoto; Okura, Hiroyuki; Saito, Yoshihiko
• Publication, Distribution, etc.: Springer Nature Publishing AG
• Publication Date: 2019-07
• Publication Date (W3CDTF): 2019-07
• Alternative Title: 冠動脈高度石灰化病変に対するスコアリングバルーンラクロスNon-Slip Elementを用いた冠動脈形成術－光干渉断層法による有用性の評価
• Periodical title: Cardiovascular intervention and therapeutics
• No. or year of volume/issue: 34 3
• Volume: 34
• Issue: 3
• Pages: 242-248
• ISSN (Periodical Title): ISSN : 1868-4300
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-03-15
• Dissertation Number: 乙第1426号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Percutaneous coronary intervention; Scoring balloon angioplasty; Coronary calcified lesion; Optical coherence tomography
• Target Audience: 一般
• Note (General): type:Thesis; Percutaneous coronary intervention (PCI) for heavily calcified lesions is challenging because these lesions are resistant to balloon dilatation and stenting. Lacrosse non-slip element (NSE) may have the potential to dilate heavily calcified lesions. We aimed to investigate predictors of successful lesion modification using Lacrosse NSE angioplasty via optical coherence tomography (OCT)-guided PCI. We investigated 32 patients with severe target lesion calcification treated with OCT-guided PCI. Successful lesion modification was defined as the complete fracture of calcification after Lacrosse NSE angioplasty. Before PCI, 172 segments with calcification were identified. After pre-dilatation using Lacrosse NSE, successful lesion modification was achieved in 117 segments (68.0%). Calcification was significantly thinner in successfully disrupted segments than in non-disrupted segments (p < 0.001). Calcification angle tended to be larger in disrupted than in non-disrupted segments (p = 0.08). Convex types were less frequently observed in disrupted than in non-disrupted segments (p < 0.001). At minimal lumen area sites, 26 segments (81.3%) were successfully modified. Similar to the overall results, the disrupted group had significantly thinner calcification than the non-disrupted group (p < 0.001). The angle of the calcified plaque was similar between the 2 groups (p = 0.39). Convex-type calcifications were less frequently observed in the disrupted group than in the non-disrupted group (p = 0.05). Receiver-operating characteristic curve analysis showed that calcification thickness < 565 μm was the best predictor of completely disrupted calcification. The thickness and shape of calcifications were predictors of successful lesion modification after Lacrosse NSE angioplasty.; 博士（医学）・乙第1426号・平成31年3月15日; © Japanese Association of Cardiovascular Intervention and Therapeutics 2018; This is a post-peer-review, pre-copyedit version of an article published in Cardiovascular intervention and therapeutics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12928-018-0553-6.; identifier:Cardiovascular intervention and therapeutics Vol.34 No.3 p.242-248 (2019 Jul); identifier:18684300; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3558; identifier:Cardiovascular intervention and therapeutics, 34(3): 242-248
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3558/1/01%e4%b9%991426%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3558/2/02%e4%b9%991426%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3558/6/03%e4%b9%991426%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s12928-018-0553-6
• Periodical Title (NCID): AA12510961; https://ci.nii.ac.jp/ncid/AA12510961
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU