Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary.

• Material Type: 博士論文
• Title: Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary.
• Author/Editor: Morioka, Sachiko; Kawaguchi, Ryuji; Yamada, Yuki; Iwai, Kana; Yoshimoto, Chiharu; Kobayashi, Hiroshi
• Author Heading: Morioka, Sachiko; Kawaguchi, Ryuji; Yamada, Yuki; Iwai, Kana; Yoshimoto, Chiharu; Kobayashi, Hiroshi
• Publication, Distribution, etc.: BioMed Central Part of Springer Nature
• Publication Date: 2019-02-25
• Publication Date (W3CDTF): 2019-02-25
• Alternative Title: 卵巣明細胞癌と類内膜癌の鑑別に関するMRIについての知見
• Periodical title: Journal of ovarian research
• No. or year of volume/issue: 12 1
• Volume: 12
• Issue: 1
• Pages: Article No.20-
• ISSN (Periodical Title): ISSN : 1757-2215
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-09-27
• Dissertation Number: 乙第1433号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Carcinoma; Endometrioid; Endometriosis; Logistic Models; Ascites; Pathology; Surgical; Adenocarcinoma; Clear Cell; Multivariate Analysis; Magnetic Resonance Imaging
• Target Audience: 一般
• Note (General): type:Thesis; BACKGROUND: Common cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC). CCC is regarded as an aggressive, chemoresistant histological subtype. Magnetic resonance imaging (MRI) offers some potential advantages to diagnose ovarian tumors compared with ultrasonography or computed tomography. This study aimed to identify MRI features that can be used to differentiate between CCC and EC. METHODS: We searched medical records of patients with ovarian cancers who underwent surgical treatment at Nara Medical University Hospital between January 2008 and September 2018; we identified 98 patients with CCC or EC who had undergone preoperative MRI. Contrasted MRI scans were performed less than 2 months before surgery. Patients were excluded from the study if they had no pathology, other pathological subtype of epithelial ovarian cancer, and/or salvage treatment for recurrence and metastatic ovarian cancer at the time of study initiation. Clinically relevant variables that were statistically significant by univariate analysis were selected for subsequent multivariate regression analysis to identify independent factors to distinguish CCC from EC. RESULTS: MRI of CCC and EC showed a large cystic heterogeneous mixed mass with mural nodules protruding into the cystic space. Univariate logistic regression analysis revealed that the growth pattern (broad-based nodular structures [multifocal/concentric sign] or polypoid structures [focal/eccentric sign]), surface irregularity (a smooth/regular surface or a rough/irregular/lobulated surface), "Width" of mural nodule, "Height-to-Width" ratio (HWR), and presence of preoperative ascites were factors that significantly differed between CCC and EC. In the multivariate logistic regression analysis, the growth pattern of the mural nodule (odds ratio [OR] = 0.69, 95% confidence interval [CI]: 0.013-0.273, p = 0.0004) and the HWR (OR = 3.71, 95% CI: 1.128-13.438, p = 0.036) were independent predictors to distinguish CCC from EC. CONCLUSIONS: In conclusion, MRI data showed that the growth pattern of mural nodules and the HWR were independent factors that could allow differentiation between CCC and EC. This finding may be helpful to predict patient prognosis before operation.; 博士（医学）・乙第1433号・令和元年9月27日; © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.; identifier:Journal of ovarian research Vol.12 No.1 Article No.20 (2019 Feb); identifier:17572215; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3669; identifier:Journal of ovarian research, 12(1): Article No.20
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3669/1/01%e4%b9%991433%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3669/2/02%e4%b9%991433%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3669/3/03%e4%b9%991433%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/s13048-019-0497-1
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU