Squamous cell carcinoma antigen as a novel candidate marker for amniotic fluid embolism.

• Material Type: 博士論文
• Title: Squamous cell carcinoma antigen as a novel candidate marker for amniotic fluid embolism.
• Author/Editor: Koike, Natsuki; Oi, Hidekazu; Naruse, Katsuhiko; Kanayama, Naohiro; Kobayashi, Hiroshi
• Author Heading: Koike, Natsuki; Oi, Hidekazu; Naruse, Katsuhiko; Kanayama, Naohiro; Kobayashi, Hiroshi
• Publication, Distribution, etc.: Wiley
• Publication Date: 2017-12
• Publication Date (W3CDTF): 2017-12
• Alternative Title: Squamous cell carcinoma antigenは羊水塞栓症診断の新しいマーカーとなり得る
• Periodical title: The journal of obstetrics and gynaecology research
• No. or year of volume/issue: 43 12
• Volume: 43
• Issue: 12
• Pages: 1815-1820
• ISSN (Periodical Title): ISSN : 1341-8076
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-09-27
• Dissertation Number: 乙第1436号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: amniotic fluid embolism; amniotic fluid-specific protein; diagnosis; squamous cell carcinoma antigen
• Target Audience: 一般
• Note (General): type:Thesis; AIM: We aimed to evaluate the clinical usefulness of serum squamous cell carcinoma (SCC) antigen for the diagnosis of amniotic fluid embolism (AFE). METHODS: Sera and information of 20 patients with AFE (autopsy-proven AFE, four cases; clinical AFE, 16 cases) were obtained from the Japan Amniotic Fluid Embolism Registration Center at Hamamatsu University School of Medicine. As controls, we included 74 gestational-age-matched healthy women who gave birth to healthy newborns during the period from December 2012 to January 2014. Receiver-operator curves (ROC) were used to evaluate the diagnostic performance of SCC levels for prediction of AFE. RESULTS: Serum SCC antigen levels in women with autopsy-proven AFE (112.0 ± 169.4 ng/mL, P = 0.001) and clinical AFE (9.5 ± 10.3 ng/mL, P = 0.004) were significantly higher than those in healthy controls with normal delivery (4.4 ± 2.2 ng/mL). On ROC analysis, the optimal cut-off value for SCC antigen levels was 7.15 ng/mL, for which the sensitivity and specificity for AFE prediction was 60.0% and 89.2%, respectively (area under the ROC, 0.785; 95% confidence interval, 0.663-0.908; P < 0.001). CONCLUSION: Serum SCC antigen may be a promising predictor of the entry of amniotic fluid into the maternal circulation, potentially serving as a candidate marker for noninvasive diagnosis of AFE.; 博士（医学）・乙第1436号・令和元年9月27日; © 2017 Japan Society of Obstetrics and Gynecology; This is the peer reviewed version of the following article: [https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/jog.13453], which has been published in final form at [https://doi.org/10.1111/jog.13453]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.; identifier:The journal of obstetrics and gynaecology research Vol.43 No.12 p.1815-1820 (2017 Dec); identifier:13418076; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3672; identifier:The journal of obstetrics and gynaecology research, 43(12): 1815-1820
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3672/1/01%e4%b9%991436%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3672/2/02%e4%b9%991436%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3672/3/03%e4%b9%991436%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1111/jog.13453
• Periodical Title (NCID): AA11082002; https://ci.nii.ac.jp/ncid/AA11082002
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU