Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy.

• Material Type: 博士論文
• Title: Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy.
• Author/Editor: Uratani, Mitsuhiro; Ota, Toyosaku; Iida, Junzo; Okazaki, Kosuke; Yamamuro, Kazuhiko; Nakanishi, Yoko; Kishimoto, Naoko; Kishimoto, Toshifumi
• Author Heading: Uratani, Mitsuhiro; Ota, Toyosaku; Iida, Junzo; Okazaki, Kosuke; Yamamuro, Kazuhiko; Nakanishi, Yoko; Kishimoto, Naoko; Kishimoto, Toshifumi
• Publication, Distribution, etc.: BioMed Central
• Publication Date: 2019-06-28
• Publication Date (W3CDTF): 2019-06-28
• Alternative Title: 近赤外線スベクトロスコピィを用いた小児期自閉スペクトラム症の前頭前野における血液動態反応の低下
• Periodical title: Child and adolescent psychiatry and mental health
• No. or year of volume/issue: 13
• Volume: 13
• Pages: Article No.29-
• ISSN (Periodical Title): ISSN : 1753-2000
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-12-05
• Dissertation Number: 乙第1442号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Pediatric autism spectrum disorder; Near-infrared spectroscopy; Prefrontal hemodynamic response; Attention; Executive function
• Target Audience: 一般
• Note (General): type:Thesis; Background: Functional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin. Methods: Twelve drug-naïve male participants, aged 7-15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy. Results: Oxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021-0.0063). Conclusion: The results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.; 博士（医学）・乙第1442号・令和元年12月5日; © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.; identifier:Child and adolescent psychiatry and mental health Vol.13 Article No.29 (2019 Jun); identifier:17532000; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3698; identifier:Child and adolescent psychiatry and mental health, 13: Article No.29
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/s13034-019-0289-9
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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