Use of a Glass Membrane Pumping Emulsification Device Improves Systemic and Tumor Pharmacokinetics in Rabbit VX2 Liver Tumor in Transarterial Chemoembolization.

• Material Type: 博士論文
• Title: Use of a Glass Membrane Pumping Emulsification Device Improves Systemic and Tumor Pharmacokinetics in Rabbit VX2 Liver Tumor in Transarterial Chemoembolization.
• Author/Editor: Masada, Tetsuya; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Taiji, Ryosuke; Sato, Takeshi; Tatsumoto, Shota; Minamiguchi, Kiyoyuki; Marugami, Nagaaki; Kichikawa, Kimihiko
• Author Heading: Masada, Tetsuya; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Taiji, Ryosuke; Sato, Takeshi; Tatsumoto, Shota; Minamiguchi, Kiyoyuki; Marugami, Nagaaki; Kichikawa, Kimihiko
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2020-02
• Publication Date (W3CDTF): 2020-02
• Alternative Title: 膜乳化デバイスによるエマルションを用いたウサギVX2肝腫瘍モデノレへの肝動脈化学塞栓術における抗腫瘍効果、薬物動態の検討
• Periodical title: Journal of vascular and interventional radiology
• No. or year of volume/issue: 31 2
• Volume: 31
• Issue: 2
• Pages: 347-351
• ISSN (Periodical Title): ISSN : 1051-0443
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2019-12-05
• Dissertation Number: 乙第1443号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: To evaluate the phamacokinetics of epirubicin in conventional transarterial chemoembolization using a developed pumping emulsification device with a microporous glass membrane in VX2 rabbits. Materials and methods: Epirubicin solution (10 mg/mL) was mixed with ethiodized oil (1:2 ratio) using the device or 3-way stopcock. Forty-eight rabbits with VX2 liver tumor implanted 2 weeks prior to transarterial chemoembolization were divided into 2 groups: a device group (n = 24) and a 3-way-stopcock group (n = 24). Next, 0.5 mL of emulsion was injected into the hepatic artery, followed by embolization using 100-300-μm microspheres. The serum epirubicin concentrations (immediately after, 5 minutes after, and 10 minutes after) and the tumor epirubicin concentrations (20 minutes after and 48 hours after) were measured after transarterial chemoembolization. Histopathologic evaluation was performed with a fluorescence microscope. Results: The area under the curve and maximum concentrations of epirubicin in plasma were 0.45 ± 0.18 μg min/mL and 0.13 ± 0.06 μg/mL, respectively, in the device group and 0.71 ± 0.45 μg min/mL and 0.22 ± 0.17 μg/mL, respectively, in the 3-way-stopcock group (P = .013 and P = .021, respectively). The mean epirubicin concentrations in VX2 tumors at 48 hours in the device group and the 3-way-stopcock group were 13.7 ± 6.71 and 7.72 ± 3.26 μg/g tissue, respectively (P = .013). The tumor necrosis ratios at 48 hours were 62 ± 11% in the device group and 51 ± 13% in the 3-way-stopcock group (P = .039). Conclusions: Conventional transarterial chemoembolization using the pumping emulsification device significantly improved the pharmacokinetics of epirubicin compared to the current standard technique using a 3-way stopcock.; 博士（医学）・乙第1443号・令和元年12月5日; Copyright © 2019 SIR. Published by Elsevier Inc. All rights reserved.; identifier:Journal of vascular and interventional radiology Vol.31 No.2 p.347-351 (2020 Feb); identifier:10510443; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3699; identifier:Journal of vascular and interventional radiology, 31(2): 347-351
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.jvir.2019.06.015
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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