Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis.

• Material Type: 博士論文
• Title: Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis.
• Author/Editor: Sasaki, Yoshiyuki; Hokuto, Daisuke; Inoue, Takashi; Nomi, Takeo; Yoshikawa, Takahiro; Matsuo, Yasuko; Koyama, Fumikazu; Sho, Masayuki
• Author Heading: Sasaki, Yoshiyuki; Hokuto, Daisuke; Inoue, Takashi; Nomi, Takeo; Yoshikawa, Takahiro; Matsuo, Yasuko; Koyama, Fumikazu; Sho, Masayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2019-11
• Publication Date (W3CDTF): 2019-11
• Alternative Title: ヒト大腸癌肝転移におけるHVEM発現の重要性について
• Periodical title: Annals of surgical oncology
• No. or year of volume/issue: 26 12
• Volume: 26
• Issue: 12
• Pages: 3982-3989
• ISSN (Periodical Title): ISSN : 1068-9265
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-12-05
• Dissertation Number: 乙第1447号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; Background: Herpesvirus entry mediator (HVEM) has been suggested to play various roles in cancer biology. The authors report that HVEM expression in tumor cells is associated with a reduction in the number of tumor-infiltrating lymphocytes and a poor prognosis after surgical resection in various human gastrointestinal cancers. This study aimed to clarify the clinical significance of HVEM expression in human colorectal liver metastasis (CRLM). Methods: This study examined the cases of 104 patients with CRLM who underwent curative liver resection at Nara Medical University between 2000 and 2014. The median follow-up period was 50.2 months. Immunohistochemical staining was performed using antibodies against HVEM, CD4, CD8, and CD45RO. Results: High HVEM expression was observed in 49 patients (47.1%) with CRLM. Expression of HVEM was not associated with age, gender, administration of preoperative chemotherapy, tumor size, number of tumors, or histologic differentiation. The high-HVEM group exhibited significantly worse overall survival (OS) than the low-HVEM group (P = 0.002). Multivariate analysis showed that high HVEM expression in CRLM, age of 70 years or older, and having five or more tumors are independent poor prognostic factors for OS (hazard ratio [HR], 3.35; 95% confidence interval [CI], 1.41-7.93; P = 0.006). The number of tumor-infiltrating CD8+ and CD45RO+ T cells was significantly lower in the high-HVEM group than in the low-HVEM group. High HVEM expression in primary colorectal cancer was significantly associated with synchronous CRLM, but not with metachronous CRLM. Conclusions: Tumor HVEM expression might play a critical role in CRLM.; 博士（医学）・乙第1447号・令和元年12月5日; © Society of Surgical Oncology 2019; This is a post-peer-review, pre-copyedit version of an article published in Annals of surgical oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-019-07625-z; identifier:Annals of surgical oncology Vol.26 No.12 p.3982-3989 (2019 Nov); identifier:10689265; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3703; identifier:Annals of surgical oncology, 26(12): 3982-3989
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1245/s10434-019-07625-z
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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