Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features.

• Material Type: 博士論文
• Title: Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features.
• Author/Editor: Minamiguchi, Kiyoyuki; Takahama, Junko; Uchiyama, Tomoko; Taiji, Ryosuke; Saito, Natsuhiko; Okada, Hiroshi; Marugami, Nagaaki; Tanase, Yasuhito; Kawaguchi, Ryuji; Ohbayashi, Chiho; Kobayashi, Hiroshi; Hirai, Toshiko; Kichikawa, Kimihiko
• Author Heading: Minamiguchi, Kiyoyuki; Takahama, Junko; Uchiyama, Tomoko; Taiji, Ryosuke; Saito, Natsuhiko; Okada, Hiroshi; Marugami, Nagaaki; Tanase, Yasuhito; Kawaguchi, Ryuji; Ohbayashi, Chiho; Kobayashi, Hiroshi; Hirai, Toshiko; Kichikawa, Kimihiko
• Publication, Distribution, etc.: Springer
• Publication Date: 2018-07
• Publication Date (W3CDTF): 2018-07
• Alternative Title: ミスマッチ修復遺伝子発現欠損を伴う子宮体癌のMRI所見と臨床像
• Periodical title: Japanese journal of radiology
• No. or year of volume/issue: 36 7
• Volume: 36
• Issue: 7
• Pages: 429-436
• ISSN (Periodical Title): ISSN : 1867-1071
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-06-30
• Dissertation Number: 甲第749号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Uterus; Endometrial carcinoma; MMR deficiency; MRI; Lynch syndrome
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: The purpose of this study was to identify the magnetic resonance imaging (MRI) features of uterine endometrial carcinoma (EC) with DNA mismatch repair (MMR) deficiency. Materials and methods: This was a retrospective study approved by our institutional review board. The study included 118 patients pathologically diagnosed as having EC in our institution from April 2014 to December 2016. Of 118 patients, 8 were excluded because of insufficient data. Immunohistochemical analysis of MMR was performed retrospectively to observe the expressions of MLH1, MSH2, MSH6, and PMS2. A tumor with MMR deficiency was detected in 17 of 110 cases (15%). Clinical background characteristics and MRI findings were reviewed. These findings were compared between MMR deficiency group and the other group as a control group. Statistical significance was determined using the Fisher's exact test and the Mann-Whitney U test, as appropriate. Results: The clinical background characteristics of patients with EC with MMR deficiency were not significantly different from those of other patients. On MRI, the tumor was significantly more often located in the lower uterine site (MMR(-) vs. MMR(+): 29.4 vs. 8.9% [p = 0.0366]). Conclusion: EC with MMR deficiency tends to be located lower in the uterus, though most other findings were not significantly different from those of EC without MMR deficiency.; 博士（医学）・甲第749号・令和2年6月30日; © Japan Radiological Society 2018; © 2018 Springer Nature Switzerland AG. Part of Springer Nature.; This is a post-peer-review, pre-copyedit version of an article published in Japanese journal of radiology. The final authenticated version is available online at: http://doi.org/10.1007/s11604-018-0741-4.; identifier:Japanese journal of radiology Vol.36 No.7 p.429-436 (2018 Jul); identifier:18671071; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3756; identifier:Japanese journal of radiology, 36(7): 429-436
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3756/1/01%e7%94%b2749%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3756/2/02%e7%94%b2749%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3756/3/03%e7%94%b2749%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3756/4/04%e7%94%b2749Figure.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s11604-018-0741-4
• Periodical Title (NCID): AA12375935; https://ci.nii.ac.jp/ncid/AA12375935
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU