Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma.

• Material Type: 博士論文
• Title: Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma.
• Author/Editor: Zuo, Shogo; Sho, Masayuki; Sawai, Toshio; Kanehiro, Hiromichi; Maeda, Kosaku; Yoshida, Makiko; Tsukada, Ryo; Nomura, Motonari; Okuyama, Hiroomi
• Author Heading: Zuo, Shogo; Sho, Masayuki; Sawai, Toshio; Kanehiro, Hiromichi; Maeda, Kosaku; Yoshida, Makiko; Tsukada, Ryo; Nomura, Motonari; Okuyama, Hiroomi
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2020-02
• Publication Date (W3CDTF): 2020-02
• Alternative Title: 神経芽腫におけるPD-L1発現と腫瘍組織浸潤リンパ球の潜在的役割について
• Periodical title: Pediatric surgery international
• No. or year of volume/issue: 36 2
• Volume: 36
• Issue: 2
• Pages: 137-143
• ISSN (Periodical Title): ISSN : 0179-0358
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-06-30
• Dissertation Number: 乙第1458号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Neuroblastoma; PD-L1; Tumor-infiltrating lymphocytes; Recurrence
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was to examine the clinical impact of the PD-L1 expression and tumor-infiltrating lymphocytes (TILs) on neuroblastoma. Methods: We evaluated the PD-L1 expression and TIL status in 31 patients with neuroblastoma who underwent a biopsy or resection by an immunohistochemical analysis. Furthermore, we performed the serial analysis of the PD-L1 status before and after chemotherapy in 15 patients. Results: Among the 31 cases, 11 (35%) showed a positive PD-L1 expression. The survival analysis showed a trend toward an association between PD-L1 positivity and a decreased overall survival. PD-L1 positivity tended to be associated with higher levels of tumor markers. In the serial analysis of the PD-L1 status, positivity was noted in 8 of 15 patients before chemotherapy and 6 after chemotherapy. Notably, all four patients with a positive PD-L1 status both before and after chemotherapy had recurrence, and 3 of them died during the follow-up period. Conclusion: Our findings suggest that the PD-L1 tumor expression might be a good biomarker for the treatment of neuroblastoma patients, especially for advanced neuroblastoma.; 博士（医学）・乙第1458号・令和2年6月30日; © Springer-Verlag GmbH Germany, part of Springer Nature 2020; This is a post-peer-review, pre-copyedit version of an article published in Pediatric surgery international. The final authenticated version is available online at: http://doi.org/10.1007/s00383-019-04616-9.; identifier:Pediatric surgery international Vol.36 No.2 p.137-143 (2020 Feb); identifier:01790358; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3759; identifier:Pediatric surgery international, 36(2): 137-143
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3759/1/01%e4%b9%991458%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3759/2/02%e4%b9%991458%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3759/6/03%e4%b9%991458%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s00383-019-04616-9
• Periodical Title (NCID): AA1068249X; https://ci.nii.ac.jp/ncid/AA1068249X
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU