Plasma Level of von Willebrand Factor Propeptide at Diagnosis: A Marker of Subsequent Renal Dysfunction in Autoimmune Rheumatic Diseases.

• Material Type: 博士論文
• Title: Plasma Level of von Willebrand Factor Propeptide at Diagnosis: A Marker of Subsequent Renal Dysfunction in Autoimmune Rheumatic Diseases.
• Author/Editor: Yada, Noritaka; Yoshimoto, Kiyomi; Kawashima, Hiromasa; Yoneima, Ryo; Nishimura, Nobushiro; Tai, Yoshiaki; Tsushima, Emiko; Miyamoto, Makiko; Ono, Shiro; Matsumoto, Masanori; Fujimoto, Takashi; Nishio, Kenji
• Author Heading: Yada, Noritaka; Yoshimoto, Kiyomi; Kawashima, Hiromasa; Yoneima, Ryo; Nishimura, Nobushiro; Tai, Yoshiaki; Tsushima, Emiko; Miyamoto, Makiko; Ono, Shiro; Matsumoto, Masanori; Fujimoto, Takashi; Nishio, Kenji
• Publication, Distribution, etc.: Sage Publications
• Publication Date: 2020-01-01
• Publication Date (W3CDTF): 2020-01-01
• Alternative Title: 診断時の血漿中von Willebrand因子プロペプチドは自己免疫性リウマチ性疾患における腎機能障害発症の予測因子となる
• Periodical title: Clinical and applied thrombosis/hemostasis
• No. or year of volume/issue: 26
• Volume: 26
• Pages: Article No.1076029620938874-
• ISSN (Periodical Title): ISSN : 1076-0296
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-09-30
• Dissertation Number: 乙第1474号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: von Willebrand factor propeptide; ADAMTS13; renal dysfunction; SLE; mutimeric analysis; rheumatic disease
• Target Audience: 一般
• Note (General): type:Thesis; Introduction: Patients with systemic autoimmune rheumatic diseases (SARDs) such as rheumatoid arthritis, systemic lupus erythematosus (SLE), Sjögren syndrome, and systemic sclerosis, which are chronic inflammatory diseases, are prone to develop renal dysfunction, which is related to vascular endothelial cell damage. Material and methods: We evaluated plasma levels of von Willebrand factor (VWF), VWF propeptide (VWF-pp), disintegrin-like and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), and VWF multimer pattern in patients with SARDs at diagnosis and investigated whether they may serve as markers to identify patients destined to develop renal dysfunction within 1 year. Renal dysfunction was defined as subsequent reduced estimated glomerular filtration rate (eGFR) by >25% or the new appearance of abnormal urine findings such as proteinuria (protein > 30 mg/dL) or hematuria (red blood cells >20/HPF in urine sediments). Overall, 63 patients with SARDs were studied. Results and conclusions: We observed a significant increase of VWF-pp and a significant decrease of ADAMTS13 in patients with SARDs compared with normal healthy controls. The highest level of VWF-pp was observed in patients with SLE among the groups. The levels of VWF and multimer pattern of VWF were not different compared with normal healthy controls. Von Willebrand factor propeptide predicted a subsequent decrease in eGFR at a cutoff point of 210% (sensitivity, 78.6%; specificity, 73.5%) and new urinary abnormal findings at a cutoff point of 232% (sensitivity, 77.8%; specificity, 77.8%) Using these cutoff points, multivariable analysis revealed that VWF-pp was a significant risk factor for renal dysfunction at an odds ratio of 8.78 and 22.8, respectively, and may lead to a new therapeutic approach to prevent vasculitis and renal dysfunction.; 博士（医学）・乙第1474号・令和2年9月30日; Copyright © The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).; identifier:Clinical and applied thrombosis/hemostasis Vol.26 Article No.1076029620938874 (2020 Jan); identifier:10760296; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3790; identifier:Clinical and applied thrombosis/hemostasis, 26: Article No.1076029620938874
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3790/1/01%e4%b9%991474%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3790/2/02%e4%b9%991474%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3790/3/03%e4%b9%991474%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1177/1076029620938874
• Periodical Title (NCID): AA11016631; https://ci.nii.ac.jp/ncid/AA11016631
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU