Associations of childhood experiences with event-related potentials in adults with autism spectrum disorder.

• Material Type: 博士論文
• Title: Associations of childhood experiences with event-related potentials in adults with autism spectrum disorder.
• Author/Editor: Okazaki, Kosuke; Ota, Toyosaku; Makinodan, Manabu; Kishimoto, Naoko; Yamamuro, Kazuhiko; Ishida, Rio; Takahashi, Masato; Yasuda, Yuka; Hashimoto, Ryota; Iida, Junzo; Kishimoto, Toshifumi
• Author Heading: Okazaki, Kosuke; Ota, Toyosaku; Makinodan, Manabu; Kishimoto, Naoko; Yamamuro, Kazuhiko; Ishida, Rio; Takahashi, Masato; Yasuda, Yuka; Hashimoto, Ryota; Iida, Junzo; Kishimoto, Toshifumi
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2020-08-10
• Publication Date (W3CDTF): 2020-08-10
• Alternative Title: 成人期自閉スペクトラム症における逆境的小児期体験の事象関連電位への影響
• Periodical title: Scientific reports
• No. or year of volume/issue: 10 1
• Volume: 10
• Issue: 1
• Pages: Article No.13447-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-12-24
• Dissertation Number: 甲第762号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Biomarkers; Diseases; Health care; Medical research; Pathogenesis; Risk factors; Signs and symptoms
• Target Audience: 一般
• Note (General): type:Thesis; Childhood maltreatment is defined as experiencing of physical, emotional and sexual abuse and neglect in childhood. Maltreatment in childhood leads to substantial psychosocial problems later in life in the general population. Individuals with autism spectrum disorder (ASD) have a higher risk of experiencing stressful and traumatic events, such as maltreatment, during childhood. Although childhood maltreatment reportedly leads to psychosocial problems in adults with ASD, the biological associations between childhood experiences and brain function in this population remain understudied. Here, we evaluated the relationships between childhood experiences and event-related potential (ERP) components during the auditory odd-ball task in adults with ASD (N = 21) and typically developed (TD) individuals (N = 22). We found that the higher the severity of sexual abuse, the larger the amplitude of P300 at Fz, Cz, C3, and C4 in individuals with ASD. Conversely, the severity of child maltreatment was associated with P300 latency at Cz and C3 in TD individuals. Moreover, full IQ was significantly associated with the MMN amplitude at Fz, Cz, C3, and C4 in TD individuals. These findings provide the first evidence that ERPs could be used to study the impacts childhood experiences on the brain of individuals with ASD and that childhood sexual abuse has salient impacts on brain function in this population.; 博士（医学）・甲第762号・令和2年12月24日; Copyright © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.; identifier:Scientific reports Vol.10 No.1 Article No.13447 (2020 Aug); identifier:20452322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3820; identifier:Scientific reports, 10(1): Article No.13447
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-020-70409-z
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3820/1/01%e7%94%b2762%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3820/2/02%e7%94%b2762%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3820/3/03%e7%94%b2762%e6%9c%ac%e6%96%87.pdf fulltext