Uncinate fasciculus disruption relates to poor recognition of negative facial emotions in Alzheimer's disease: a cross-sectional diffusion tensor imaging study.

• Material Type: 博士論文
• Title: Uncinate fasciculus disruption relates to poor recognition of negative facial emotions in Alzheimer's disease: a cross-sectional diffusion tensor imaging study.
• Author/Editor: Takahashi, Masato; Kitamura, Soichiro; Matsuoka, Kiwamu; Yoshikawa, Hiroaki; Yasuno, Fumihiko; Makinodan, Manabu; Kimoto, Sohei; Miyasaka, Toshiteru; Kichikawa, Kimihiko; Kishimoto, Toshifumi
• Author Heading: Takahashi, Masato; Kitamura, Soichiro; Matsuoka, Kiwamu; Yoshikawa, Hiroaki; Yasuno, Fumihiko; Makinodan, Manabu; Kimoto, Sohei; Miyasaka, Toshiteru; Kichikawa, Kimihiko; Kishimoto, Toshifumi
• Publication, Distribution, etc.: John Wiley & Sons, Inc.
• Publication Date: 2020-05
• Publication Date (W3CDTF): 2020-05
• Alternative Title: アルツハイマー病における不快表情認知と鉤状束との関連：横断的拡散テンソル画像研究
• Periodical title: Psychogeriatrics
• No. or year of volume/issue: 20 3
• Volume: 20
• Issue: 3
• Pages: 296-303
• ISSN (Periodical Title): ISSN : 1346-3500
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-12-24
• Dissertation Number: 甲第763号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Alzheimer's disease; diffusion tensor imaging; facial emotion recognition; tractography
• Target Audience: 一般
• Note (General): type:Thesis; Background: Recognising facial emotions involves visual and emotional information processing. Patients with dementia, including dementia of Alzheimer's type (DAT), are known to poorly recognise facial emotions, especially negative facial emotions. In this study, we aimed to assess if DAT patients exhibit poor facial emotional recognition, and to identify a neural basis for how poor facial emotional recognition might occur. Methods: Magnetic resonance imaging and diffusion tensor imaging (DTI) analysis were conducted in 20 DAT patients and 15 cognitive normal (CN) subjects. The uncinate fasciculus (UF), inferior longitudinal fasciculus, and inferior fronto-occipital fasciculus were delineated by deterministic tractography. DTI parameters were calculated for each fibre. Facial emotion recognition was evaluated with the Facial Emotion Selection Test (FEST). The relationships between FEST scores and DTI parameters in each fibre were measured by partial correlation analyses with age, gender, and the Mini-Mental State Examination as covariates. Group-wise comparisons between DAT and CN subjects were performed for each DTI parameter in each fibre. Results: DAT patients showed lower FEST negative emotion scores than CN subjects (P < 0.05). The score of negative emotion subscale was negatively correlated (r = -0.770, P < 0.001) to mean diffusivity of the left UF in DAT patients. There were no relationships between negative emotion subscale and the other fibre tracts. DAT patients showed no differences in the DTI parameters for each fibre compared to CN subjects. Conclusions: DAT-related prefrontal-limbic network dysfunction is associated with poor recognition of unpleasant emotions; consequently, worse facial recognition of negative emotion is observed in DAT patients.; 博士（医学）・甲第763号・令和2年12月24日; © 2020 Japanese Psychogeriatric Society; This is the peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/full/10.1111/psyg.12498, which has been published in final form at https://doi.org/10.1111/psyg.12498 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.; identifier:Psychogeriatrics Vol.20 No.3 p.296-303 (2020 May); identifier:13463500; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3821; identifier:Psychogeriatrics, 20(3): 296-303
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1111/psyg.12498
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3821/1/01%e7%94%b2763%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3821/2/02%e7%94%b2763%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3821/6/03%e7%94%b2763%e6%9c%ac%e6%96%87.pdf fulltext