Lipid Core Plaque Distribution Using Near-infrared Spectroscopy Is Consistent with Pathological Evaluation in Carotid Artery Plaques.

• Material Type: 博士論文
• Title: Lipid Core Plaque Distribution Using Near-infrared Spectroscopy Is Consistent with Pathological Evaluation in Carotid Artery Plaques.
• Author/Editor: Kotsugi, Masashi; Nakagawa, Ichiro; Hatakeyama, Kinta; Park, HunSoo; Sato, Fumiya; Furuta, Takanori; Nishimura, Fumihiko; Yamada, Shuichi; Motoyama, Yasushi; Park, Young-Soo; Nakase, Hiroyuki
• Author Heading: Kotsugi, Masashi; Nakagawa, Ichiro; Hatakeyama, Kinta; Park, HunSoo; Sato, Fumiya; Furuta, Takanori; Nishimura, Fumihiko; Yamada, Shuichi; Motoyama, Yasushi; Park, Young-Soo; Nakase, Hiroyuki
• Publication, Distribution, etc.: Japan Neurosurgical Society
• Publication Date: 2020-10-15
• Publication Date (W3CDTF): 2020-10-15
• Alternative Title: 頚動脈プラーク摘出標本を用いた近赤外線分光法によるプラーク分布と病理学的評価の整合性
• Periodical title: Neurologia medico-chirurgica
• No. or year of volume/issue: 60 10
• Volume: 60
• Issue: 10
• Pages: 499-506
• ISSN (Periodical Title): ISSN : 0470-8105
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-12-24
• Dissertation Number: 乙第1482号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: imaging modalities; carotid artery stenosis; lipid plaque; NIRS-IVUS; carotid artery stenting
• Target Audience: 一般
• Note (General): type:Thesis; Carotid artery stenting (CAS) is performed as a treatment for carotid artery stenosis. However, lipid-rich plaques cause embolic complications and sequelae. Near-infrared spectroscopy (NIRS) can identify lipid components by applying a near-infrared absorption pattern, and the distribution of lipid components can be evaluated as the maximum lipid core burden index (maxLCBI). Intravascular ultrasound (IVUS) equipped with NIRS has been clinically applied recently, and its diagnostic usefulness and validation have been reported for coronary arteries; however, its consistency with actual pathological diagnosis in carotid artery lesions has not been validated. In this study, we investigated the consistency between the maxLCBI values and histopathological diagnoses. Patients with cervical carotid artery stenosis who underwent carotid endarterectomy (CEA) were examined in this prospective study. Pathological diagnosis was determined after NIRS evaluation, which was performed on the extracted plaques ex vivo. The histological slices of decalcified and paraffin-embedded sections were stained by hematoxylin-eosin (HE) and Elastica van Gieson (EVG), and for low-density lipoprotein (LDL), C-reactive protein (CRP), CD68, and glycophorin A. The correlation between maxLCBI values and histological findings. Seventy lesions assessed by NIRS were pathologically analyzed. There was a positive linear correlation between maxLCBI values and pathological findings as determined by HE (angle), HE (area%), EVG, CRP, and CD68 staining (respectively, r = 0.624, p <0.001; r = 0.578, p <0.001; r = 0.534, p <0.001; r = 0.723, p <0.001; r = 0.653, p <0.001). In conclusion, the maxLCBI values assessed by NIRS showed a significant positive linear correlation with pathological evaluations in carotid lesions. The maxLCBI values in carotid arteries are consistent with pathological evaluations.; 博士（医学）・乙第1482号・令和2年12月24日; Copyright© 2020 by The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License(https://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Neurologia medico-chirurgica Vol.60 No.10 p.499-506 (2020 Oct); identifier:04708105; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3827; identifier:Neurologia medico-chirurgica, 60(10): 499-506
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3827/1/01%e4%b9%991482%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3827/2/02%e4%b9%991482%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3827/3/03%e4%b9%991482%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2176/nmc.oa.2020-0154
• Periodical Title (NCID): AN00358613; https://ci.nii.ac.jp/ncid/AN00358613
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU