27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action.

• Material Type: 博士論文
• Title: 27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action.
• Author/Editor: Matsubayashi, Masaya; Sakaguchi, Yoshihiko M; Sahara, Yoshiki; Nanaura, Hitoki; Kikuchi, Sotaro; Asghari, Arvand; Bui, Linh; Kobashigawa, Shinko; Nakanishi, Mari; Nagata, Riko; Matsui, Takeshi K; Kashino, Genro; Hasegawa, Masatoshi; Takasawa, Shin; Eriguchi, Masahiro; Tsuruya, Kazuhiko; Nagamori, Shushi; Sugie, Kazuma; Nakagawa, Takahiko; Takasato, Minoru; Umetani, Michihisa; Mori, Eiichiro
• Author Heading: Matsubayashi, Masaya; Sakaguchi, Yoshihiko M; Sahara, Yoshiki; Nanaura, Hitoki; Kikuchi, Sotaro; Asghari, Arvand; Bui, Linh; Kobashigawa, Shinko; Nakanishi, Mari; Nagata, Riko; Matsui, Takeshi K; Kashino, Genro; Hasegawa, Masatoshi; Takasawa, Shin; Eriguchi, Masahiro; Tsuruya, Kazuhiko; Nagamori, Shushi; Sugie, Kazuma; Nakagawa, Takahiko; Takasato, Minoru; Umetani, Michihisa; Mori, Eiichiro
• Publication, Distribution, etc.: Wiley
• Publication Date: 2021-01
• Publication Date (W3CDTF): 2021-01
• Alternative Title: 27ヒドロキシコレステロールはエストロゲン受容体を介してヒトSLC22A12の発現を制御する
• Periodical title: FASEB journal
• No. or year of volume/issue: 35 1
• Volume: 35
• Issue: 1
• Pages: Article No.e21262-
• ISSN (Periodical Title): ISSN : 0892-6638
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-03-15
• Dissertation Number: 甲第772号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: 27-hydroxycholesterol; estrogen receptor; transcriptional regulatory element; uric acid
• Target Audience: 一般
• Note (General): type:Thesis; The excretion and reabsorption of uric acid both to and from urine are tightly regulated by uric acid transporters. Metabolic syndrome conditions, such as obesity, hypercholesterolemia, and insulin resistance, are believed to regulate the expression of uric acid transporters and decrease the excretion of uric acid. However, the mechanisms driving cholesterol impacts on uric acid transporters have been unknown. Here, we show that cholesterol metabolite 27-hydroxycholesterol (27HC) upregulates the uric acid reabsorption transporter URAT1 encoded by SLC22A12 via estrogen receptors (ER). Transcriptional motif analysis showed that the SLC22A12 gene promoter has more estrogen response elements (EREs) than other uric acid reabsorption transporters such as SLC22A11 and SLC22A13, and 27HC-activated SLC22A12 gene promoter via ER through EREs. Furthermore, 27HC increased SLC22A12 gene expression in human kidney organoids. Our results suggest that in hypercholesterolemic conditions, elevated levels of 27HC derived from cholesterol induce URAT1/SLC22A12 expression to increase uric acid reabsorption, and thereby, could increase serum uric acid levels.; 博士（医学）・甲第772号・令和3年3月15日; © 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.; identifier:FASEB journal Vol.35 No.1 Article No.e21262 (2021 Jan); identifier:08926638; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3896; identifier:FASEB journal, 35(1): Article No.e21262
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3896/1/01%e7%94%b2772%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3896/2/02%e7%94%b2772%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3896/3/03%e7%94%b2772%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3896/4/04%e7%94%b2772Suppl..pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1096/fj.202002077R
• Periodical Title (NCID): AA1066874X; https://ci.nii.ac.jp/ncid/AA1066874X
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU