Identification of Novel Genes Related to Tooth Morphogenesis.

• Material Type: 博士論文
• Title: Identification of Novel Genes Related to Tooth Morphogenesis.
• Author/Editor: Nakagawa, Masato; Takeo, Makoto; Ogawa, Miho; Yuge, Yohei; Yasukawa, Masato; Tokita, Tomomi; Ishida, Kentaro; Ikeda, Etsuko; Kirita, Tadaaki; Tsuji, Takashi
• Author Heading: Nakagawa, Masato; Takeo, Makoto; Ogawa, Miho; Yuge, Yohei; Yasukawa, Masato; Tokita, Tomomi; Ishida, Kentaro; Ikeda, Etsuko; Kirita, Tadaaki; Tsuji, Takashi
• Publication, Distribution, etc.: 日本再生歯科医学会
• Publication Date: 2020
• Publication Date (W3CDTF): 2020
• Alternative Title: 歯の形態形成に関与する新規遺伝子の解明
• Periodical title: Journal of oral tissue engineering
• No. or year of volume/issue: 18 2
• Volume: 18
• Issue: 2
• Pages: 41-54
• ISSN (Periodical Title): ISSN : 1348-9623
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-03-15
• Dissertation Number: 甲第790号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: development; gene ontology; microarray analysis; qPCR; in situ hybridization
• Target Audience: 一般
• Note (General): type:Thesis; Tooth development is controlled by body plan during the fetal period, the generation of teeth from tooth germ is induced by the epithelial-mesenchymal interaction. Spatiotemporal regulation of tooth morphogenesis is supported by gene expression. Although many of the genes involved in tooth development are known, the molecular mechanism underlying tooth morphogenesis is not completely understood. For a comprehensive understanding of tooth development, the elucidation of unknown genes is necessary. In this study, to identify unknown genes involved in tooth development, we performed genome-wide analysis at each stage of tooth development and identified 17 genes with high levels of expression and large changes in expression. In addition, we performed qPCR and in situ hybridization analyses to elucidate the spatiotemporal regulation, such as the regulation that occurs around or in the entire tooth germ, enamel knots, epithelium, and mesenchyme. These results show that these characteristic genes may play important roles in each time period or region of tooth development, and the elucidation of the functions of these genes will lead to an integrated understanding of the process of tooth development.; 博士（医学）・甲第790号・令和3年3月15日; 発行元である日本再生歯科医学会の許諾を得て登録（2021年6月29日付）; ジャーナル公式サイト（日本再生歯科医学会HP内）：http://www.jarde.jp/zasshi/e/18-2-1.html; identifier:Journal of oral tissue engineering Vol.18 No.2 p.41-54 (2020); identifier:13489623; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3914; identifier:Journal of oral tissue engineering, 18(2): 41-54
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.11223/jarde.18.41
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3914/1/01%e7%94%b2790%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3914/2/02%e7%94%b2790%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3914/3/03%e7%94%b2790%e6%9c%ac%e6%96%87.pdf fulltext