Handgrip Strength Is an Independent Predictor of Cardiovascular Outcomes in Diabetes Mellitus.

• Material Type: 博士論文
• Title: Handgrip Strength Is an Independent Predictor of Cardiovascular Outcomes in Diabetes Mellitus.
• Author/Editor: Morikawa, Yoshinobu; Kawakami, Rika; Horii, Manabu; Yamamoto, Yuta; Yabuta, Matahiro; Saito, Yoshihiko
• Author Heading: Morikawa, Yoshinobu; Kawakami, Rika; Horii, Manabu; Yamamoto, Yuta; Yabuta, Matahiro; Saito, Yoshihiko
• Publication, Distribution, etc.: International Heart Journal Association (インターナショナル・ハート・ジャーナル刊行会)
• Publication Date: 2021
• Publication Date (W3CDTF): 2021
• Alternative Title: 握力は、糖尿病患者の心血管イベントの独立した予測因子である
• Periodical title: International heart journal
• No. or year of volume/issue: 62 1
• Volume: 62
• Issue: 1
• Pages: 50-56
• ISSN (Periodical Title): ISSN : 1349-2365
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-03-15
• Dissertation Number: 乙第1493号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Skeletal muscle strength; Sarcopenia; Cardiovascular disease
• Target Audience: 一般
• Note (General): type:Thesis; Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and an elevated prevalence of sarcopenia. However, the relationship between cardiovascular events and sarcopenia in patients with DM remains unclear. This study examined this relationship and investigated the predictors of cardiovascular events in this population.This study enrolled 161 patients with DM and no history of cardiovascular diseases who were admitted to our hospital for the treatment of DM between September 2012 and December 2015. Patients were divided into sarcopenia and non-sarcopenia groups, and were followed until March 2019. The primary endpoint was major adverse cardiovascular events (MACE).The mean age was 65.9 ± 1.8 years old and the mean follow-up period was 4.1 ± 0.8 years. The log-rank test indicated that MACE differed significantly between the two groups (P < 0.0001). Multivariate Cox hazard analysis identified the cardio-ankle vascular index (CAVI) and handgrip strength as independent predictors of MACE (hazard ratio [HR] = 1.18, P = 0.039; and HR = 0.70, P = 0.016, respectively).Handgrip strength is an indicator of sarcopenia in diabetic patients, and together with CAVI it was independently associated with the incidence of MACE. This suggests that the handgrip strength test might be useful in the management of patients with DM at high risk of cardiovascular outcomes.; 博士（医学）・乙第1493号・令和3年3月15日; © 2021 by the International Heart Journal Association; 発行元であるインターナショナル・ハート・ジャーナル刊行会の許諾を得て登録（2021年6月23日付）; ジャーナル公式サイト（J-STAGE内）：https://doi.org/10.1536/ihj.20-677; identifier:International heart journal Vol.62 No.1 p.50-56 (2021); identifier:13492365; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3917; identifier:International heart journal, 62(1): 50-56
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1536/ihj.20-677
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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