Clinical Importance of CD200 Expression in Colorectal Liver Metastasis.

• Material Type: 博士論文
• Title: Clinical Importance of CD200 Expression in Colorectal Liver Metastasis.
• Author/Editor: Matsuo, Yasuko; Sho, Masayuki; Nomi, Takeo; Hokuto, Daisuke; Yoshikawa, Takahiro; Kamitani, Naoki; Nakamura, Kota; Iwasa, Yosuke
• Author Heading: Matsuo, Yasuko; Sho, Masayuki; Nomi, Takeo; Hokuto, Daisuke; Yoshikawa, Takahiro; Kamitani, Naoki; Nakamura, Kota; Iwasa, Yosuke
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-09
• Publication Date (W3CDTF): 2021-09
• Alternative Title: 大腸癌肝転移におけるCD200発現の臨床的意義
• Periodical title: Annals of surgical oncology
• No. or year of volume/issue: 28 9
• Volume: 28
• Issue: 9
• Pages: 5362-5372
• ISSN (Periodical Title): ISSN : 1068-9265
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-03-15
• Dissertation Number: 乙第1497号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; Background: Approximately 30% of patients diagnosed with colorectal cancer (CRC) develop liver metastases. We evaluated the role of CD200, a potent immunosuppressive molecule, in colorectal liver metastases (CRLM). Methods: We examined 110 patients who underwent curative liver resection for CRLM at our institution between 2000 and 2016. Based on the results of immunohistochemical analysis, the patients were divided into high-CD200 (n = 47) and low-CD200 (n = 63) expression groups. The relationships between CD200 expression and various clinicopathological outcomes were investigated. Results: The overall survival (OS) of patients in the high-CD200 group was significantly worse than that in the low-CD200 group (p = 0.009). Multivariate analysis showed that the independent prognostic factors in CRLM were maximum tumor size > 30 mm (p = 0.002), preoperative carcinoembryonic antigen level > 20 ng/mL (p < 0.001), primary CRC N2-3 (p = 0.049), and high-CD200 expression (p = 0.004). Furthermore, CD4+, CD8+, and CD45RO+ tumor-infiltrating lymphocytes in CRLM were significantly higher in the low-CD200 group than in the high-CD200 group (p = 0.005, p = 0.001, and p < 0.001, respectively). In addition, patients who had received preoperative chemotherapy had higher CD200 expression than those who had not received preoperative chemotherapy, and OS was significantly worse in patients in the high-CD200 group who had received preoperative chemotherapy. Conclusions: CD200 expression was an independent prognostic factor in CRLM. CD200 may play a critical role in tumor immunity in CRLM, and can therefore be used as a potential therapeutic target in CRLM.; 博士（医学）・乙第1497号・令和3年3月15日; © 2021. Society of Surgical Oncology.; © Springer Nature Singapore Pte Ltd. 2020; This is a post-peer-review, pre-copyedit version of an article published in Annals of Surgical Oncology. The final authenticated version is available online at: https://doi.org/10.1245/s10434-020-09471-w.; identifier:Annals of surgical oncology Vol.28 No.9 p.5362-5372 (2021 Sep); identifier:10689265; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3921; identifier:Annals of surgical oncology, 28(9): 5362-5372
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3921/1/01%e4%b9%991497%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3921/2/02%e4%b9%991497%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3921/3/03%e4%b9%991497%e6%9c%ac%e6%96%87pdf.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1245/s10434-020-09471-w
• Periodical Title (NCID): AA11016573; https://ci.nii.ac.jp/ncid/AA11016573
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU