Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis.

• Material Type: 博士論文
• Title: Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis.
• Author/Editor: Yokotani, Tomoyo; Ikeda, Naoya; Hirao, Tomoko; Tanaka, Yukimi; Morita, Kohei; Fujii, Tomomi; Ohbayashi, Chiho; Nakamura, Takashi; Kobayashi, Toyoki; Sho, Masayuki
• Author Heading: Yokotani, Tomoyo; Ikeda, Naoya; Hirao, Tomoko; Tanaka, Yukimi; Morita, Kohei; Fujii, Tomomi; Ohbayashi, Chiho; Nakamura, Takashi; Kobayashi, Toyoki; Sho, Masayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-04
• Publication Date (W3CDTF): 2021-04
• Alternative Title: 乳癌術前化学療法において腋窩リンパ節転移が陰性化するための効果予測因子の検討
• Periodical title: Surgery today
• No. or year of volume/issue: 51 4
• Volume: 51
• Issue: 4
• Pages: 595-604
• ISSN (Periodical Title): ISSN : 0941-1291
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-03-15
• Dissertation Number: 乙第1498号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Tumor-infiltrating lymphocytes; Axillary dissection; Breast cancer; Neoadjuvant chemotherapy; Axillary pathological complete response
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). Methods: The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis. Results: We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND. Conclusion: TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease.; 博士（医学）・乙第1498号・令和3年3月15日; © Springer Nature Singapore Pte Ltd. 2020; This is a post-peer-review, pre-copyedit version of an article published in Surgery today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-020-02157-6.; identifier:Surgery today Vol.51 No.4 p.595-604 (2021 Apr); identifier:09411291; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3924; identifier:Surgery today, 51(4): 595-604
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3924/1/01%e4%b9%991498%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3924/2/02%e4%b9%991498%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3924/6/03%e4%b9%991498%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s00595-020-02157-6
• Periodical Title (NCID): AA10824685; https://ci.nii.ac.jp/ncid/AA10824685
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU