Subtype I (intrinsic) adenomyosis is an independent risk factor for dienogest-related serious unpredictable bleeding in patients with symptomatic adenomyosis.

• Material Type: 博士論文
• Title: Subtype I (intrinsic) adenomyosis is an independent risk factor for dienogest-related serious unpredictable bleeding in patients with symptomatic adenomyosis.
• Author/Editor: Matsubara, Sho; Kawaguchi, Ryuji; Akinishi, Mika; Nagayasu, Mika; Iwai, Kana; Niiro, Emiko; Yamada, Yuki; Tanase, Yasuhito; Kobayashi, Hiroshi
• Author Heading: Matsubara, Sho; Kawaguchi, Ryuji; Akinishi, Mika; Nagayasu, Mika; Iwai, Kana; Niiro, Emiko; Yamada, Yuki; Tanase, Yasuhito; Kobayashi, Hiroshi
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2019-11-27
• Publication Date (W3CDTF): 2019-11-27
• Alternative Title: 子宮内膜側に発症する (Subtypel) 子宮腺筋症は黄体ホルモン療法による多量性器出血の危険因子である
• Periodical title: Scientific reports
• No. or year of volume/issue: 9 1
• Volume: 9
• Issue: 1
• Pages: Article No.17654-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-09-29
• Dissertation Number: 甲第800号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Drug regulation; Risk factors
• Target Audience: 一般
• Note (General): type:Thesis; We aimed to retrospectively analyze the risk factors of a continuous dienogest (DNG) therapy for serious unpredictable bleeding in patients with symptomatic adenomyosis. This is a retrospective study based on data extracted from medical records of 84 women treated with 2 mg of DNG orally each day between 2008 and 2017. 47 subjects were excluded from the original analyses due to an inadequate subcategorization into subtype I and subtype II and a lack of hemoglobin levels. The influence of various independent variables on serious unpredictable bleeding was assessed. Of the 37 eligible patients who received the continuous DNG therapy, 14 patients experienced serious unpredictable bleeding. Univariate analysis revealed that the serious bleeding group had subtype I adenomyosis (P = 0.027). There was no correlation between age, parity, minimum hemoglobin level before treatment, previous endometrial curettage, and duration of DNG administration, or uterine or adenomyosis size and the serious bleeding. A DNG-related serious unpredictable bleeding is associated with the structural type of adenomyosis (subtype I) in patients with symptomatic adenomyosis.; 博士（医学）・甲第800号・令和3年9月29日; © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.; identifier:Scientific reports Vol.9 No.1 Article No.17654 (2019 Nov); identifier:20452322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3949; identifier:Scientific reports, 9(1): Article No.17654
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3949/1/01%e7%94%b2800%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3949/2/02%e7%94%b2800%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3949/3/03%e7%94%b2800%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3949/4/04%e7%94%b2800Suppl..pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-019-54096-z
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU