Effect of preoperative asymptomatic renal dysfunction on the clinical course after colectomy for colon cancer.

• Material Type: 博士論文
• Title: Effect of preoperative asymptomatic renal dysfunction on the clinical course after colectomy for colon cancer.
• Author/Editor: Obara, Shinsaku; Koyama, Fumikazu; Kuge, Hiroyuki; Nakamoto, Takayuki; Ikeda, Naoya; Iwasa, Yosuke; Takei, Takeshi; Sadamitsu, Tomomi; Fujimoto, Kosuke; Harada, Suzuka; Sho, Masayuki
• Author Heading: Obara, Shinsaku; Koyama, Fumikazu; Kuge, Hiroyuki; Nakamoto, Takayuki; Ikeda, Naoya; Iwasa, Yosuke; Takei, Takeshi; Sadamitsu, Tomomi; Fujimoto, Kosuke; Harada, Suzuka; Sho, Masayuki
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-01
• Publication Date (W3CDTF): 2022-01
• Alternative Title: 無症候性腎機能障害が結腸癌術後の臨床経過に及ぼす影響
• Periodical title: Surgery today
• No. or year of volume/issue: 52 1
• Volume: 52
• Issue: 1
• Pages: 106-113
• ISSN (Periodical Title): ISSN : 0941-1291
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-12-21
• Dissertation Number: 甲第804号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Colon cancer; Renal dysfunction; Postoperative complication; Estimated glomerular filtration rate
• Target Audience: 一般
• Note (General): type:Thesis; Purpose: To evaluate the effect of mild renal dysfunction on the clinical course after colectomy in patients with colon cancer. Methods: The subjects of this retrospective study were 263 patients who underwent surgical resection for colon cancer at our hospital between 2011 and 2015. Renal function was assessed based on preoperative estimated glomerular filtration rate (eGFR) values. Patients were divided into groups based on their eGFR value of 55 ml/min/1.73 m2. The Mann-Whitney U test, chi-square or Fisher exact test, and log-rank test were used in the data analysis. Results: There were 59 patients (22.4%) in the low eGFR group and 204 patients in the normal eGFR group. There were differences between the groups in age, comorbidities, and the levels of hemoglobin, albumin, and serum creatinine. The overall postoperative complication rate, frequency of severe complications, and length of stay were significantly higher in the low eGFR group than in the normal eGFR group. Multivariate analysis revealed that low eGFR was the only independent risk factor for severe complications (Clavien-Dindo classification III/IV). There were no differences in survival between the groups. Conclusion: Preoperative asymptomatic renal dysfunction may be correlated with the development of postoperative complications and a possible significant risk factor for severe complications after colon cancer surgery.; 博士（医学）・甲第804号・令和3年12月21日; © 2021. Springer Nature Singapore Pte Ltd.; The version of record of this article, first published in Surgery Today, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00595-021-02363-w.; 発行元が定める登録猶予期間終了の後、本文を登録予定（2023.01）; identifier:Surgery today Vol.52 No.1 p.106-113 (2022 Jan); identifier:09411291; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3953; identifier:Surgery today, 52(1): 106-113
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s00595-021-02363-w
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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