Potential role of surgical resection for pancreatic cancer in the very elderly.

• Material Type: 博士論文
• Title: Potential role of surgical resection for pancreatic cancer in the very elderly.
• Author/Editor: Kinoshita, Shoichi; Sho, Masayuki; Yanagimoto, Hiroaki; Satoi, Sohei; Akahori, Takahiro; Nagai, Minako; Nishiwada, Satoshi; Yamamoto, Tomohisa; Hirooka, Satoshi; Yamaki, So; Ikeda, Naoya; Kwon, A-Hon; Nakajima, Yoshiyuki
• Author Heading: Kinoshita, Shoichi; Sho, Masayuki; Yanagimoto, Hiroaki; Satoi, Sohei; Akahori, Takahiro; Nagai, Minako; Nishiwada, Satoshi; Yamamoto, Tomohisa; Hirooka, Satoshi; Yamaki, So; Ikeda, Naoya; Kwon, A-Hon; Nakajima, Yoshiyuki
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2015-05
• Publication Date (W3CDTF): 2015-05
• Alternative Title: 80歳以上の高齢者膵癌に対する膵切除の意義
• Periodical title: Pancreatology
• No. or year of volume/issue: 15 3
• Volume: 15
• Issue: 3
• Pages: 240-246
• ISSN (Periodical Title): ISSN : 1424-3903
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2021-12-21
• Dissertation Number: 乙第1513号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Elderly; Pancreatic adenocarcinoma; Pancreatectomy; Chemotherapy; Surgery; Prognosis
• Target Audience: 一般
• Note (General): type:Thesis; Background: There is increasing need to evaluate the surgical indication of pancreatic cancer in very elderly patients. However, the available clinical data are limited, and the optimal treatment is still controversial. The aim of this study was to evaluate the benefit of pancreatic resection in pancreatic cancer patients over the age of 80. Methods: Between 2005 and 2012, 26 octogenarian patients who received pancreatic resection and 20 who received chemotherapy for pancreatic cancer were retrospectively reviewed. Clinicopathological factors, chemotherapy administration status, and survival were compared. Univariate and multivariate analysis of prognostic factors for survival was performed. Results: Postoperative major complication rate was 8%, with no mortality. The one-year survival rate and median survival time of the surgery and chemotherapy groups were 50% and 45%, and 12.4 months and 11.7 months, respectively (P = 0.263). Of the 26 resected cases, 6 completed the planned adjuvant chemotherapy treatment course. The median survival time of those 6 completed cases was significantly longer than that of the 20 not completed cases (23.4 versus 10.0 months, P = 0.034). Furthermore, a multivariate analysis of the 26 resected cases showed that distant metastasis (HR 3.206, 95%CI 1.005-10.22, P = 0.049) and completion of the planned adjuvant therapy (HR 4.078, 95%CI 1.162-14.30, P = 0.028) were independent prognostic factors of surgical resection. Conclusions: Surgical resection was safe, but not superior to chemotherapy for pancreatic cancer in octogenarians. In the very elderly, only selected patients may benefit from pancreatic resection.; 博士（医学）・乙第1513号・令和3年12月21日; Copyright © 2015 IAP and EPC. Published by Elsevier, a division of RELX India, Pvt. Ltd. All rights reserved.; identifier:Pancreatology Vol.15 No.3 p.240-246 (2015 May-Jun); identifier:14243903; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3958; identifier:Pancreatology, 15(3): 240-246
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3958/1/01%e4%b9%991513%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3958/2/02%e4%b9%991513%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3958/3/03%e4%b9%991513%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.pan.2015.03.015
• Periodical Title (NCID): AA11583711; https://ci.nii.ac.jp/ncid/AA11583711
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU