Association between chronic kidney disease and new-onset dyslipidemia: The Japan Specific Health Checkups (J-SHC) study.

• Material Type: 博士論文
• Title: Association between chronic kidney disease and new-onset dyslipidemia: The Japan Specific Health Checkups (J-SHC) study.
• Author/Editor: Kosugi, Takaaki; Eriguchi, Masahiro; Yoshida, Hisako; Tasaki, Hikari; Fukata, Fumihiro; Nishimoto, Masatoshi; Matsui, Masaru; Samejima, Ken-ichi; Iseki, Kunitoshi; Fujimoto, Shouichi; Konta, Tsuneo; Moriyama, Toshiki; Yamagata, Kunihiro; Narita, Ichiei; Kasahara, Masato; Shibagaki, Yugo; Kondo, Masahide; Asahi, Koichi; Watanabe, Tsuyoshi; Tsuruya, Kazuhiko; Japan Specific Health Checkups (J-SHC) Study Group
• Author Heading: Kosugi, Takaaki; Eriguchi, Masahiro; Yoshida, Hisako; Tasaki, Hikari; Fukata, Fumihiro; Nishimoto, Masatoshi; Matsui, Masaru; Samejima, Ken-ichi; Iseki, Kunitoshi; Fujimoto, Shouichi; Konta, Tsuneo; Moriyama, Toshiki; Yamagata, Kunihiro; Narita, Ichiei; Kasahara, Masato; Shibagaki, Yugo; Kondo, Masahide; Asahi, Koichi; Watanabe, Tsuyoshi; Tsuruya, Kazuhiko; Japan Specific Health Checkups (J-SHC) Study Group
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-09
• Publication Date (W3CDTF): 2021-09
• Alternative Title: 慢性腎臓病と脂質異常症の新規発症との関連の検討 : The Japan Specific Health Checkups (J-SHC) study
• Periodical title: Atherosclerosis
• No. or year of volume/issue: 332
• Volume: 332
• Pages: 24-32
• ISSN (Periodical Title): ISSN : 0021-9150
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Dissertation Number: 甲第823号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Chronic kidney disease; Dyslipidemia; Hypertriglyceridemia; Hypo-high-density lipoprotein cholesterolemia; Hyper-low-density lipoprotein cholesterolemia
• Target Audience: 一般
• Note (General): type:Thesis; Background and aims: Dyslipidemias are common among patients with chronic kidney disease (CKD) and are a major risk factor for cardiovascular disease. This study aimed to investigate the association between early-stage CKD and new-onset dyslipidemia for each lipid profile. Methods: This nationwide longitudinal study included data from the Japan Specific Health Checkups (J-SHC) Study. New-onset dyslipidemia was indicated by hypertriglyceridemia (High-TG; ≥150 mg/dL), hyper-LDL cholesterolemia (High-LDL-C; ≥140 mg/dL), or hypo-HDL chelesterolemia (Low-HDL-C; <40 mg/dL) levels according to the guideline of Japan Atherosclerosis Society, or High-TG/HDL-C ratio (≥3.5) which was a good predictor of atherosclerosis. The incidence of new-onset dyslipidemia was compared between participants with and without CKD. Survival curves were used to analyze the incidence of each dyslipidemia. Results: Of 289,462 participants with a median follow-up period of 3 years, the incidence of High-TG, High-LDL-C, Low-HDL-C, and High-TG/HDL-C ratios were 64.4/1000 person-years, 83.1/1000 person-years, 14.5/1000 person-years, and 39.6/1000 person-years, respectively. The adjusted hazard ratios (95% confidence intervals) for High-TG, High-LDL-C, Low-HDL-C, and High-TG/HDL-C ratio were 1.09 (1.05-1.13), 0.99 (0.95-1.04), 1.12 (1.05-1.18), and 1.14 (1.09-1.18), respectively, in CKD participants as compared to non-CKD participants. Decreased eGFR and presence of proteinuria were independently associated with higher risks for new-onset of High-TG, Low-HDL-C, and High-TG/HDL-C ratios. Conclusions: CKD was associated with a higher risk of new-onset High-TG, Low-HDL-C, and High-TG/HDL-C ratios, but not High-LDL-C, in the general population. These CKD-specific lipid abnormalities may explain the residual risk for CKD-related cardiovascular disease.; 博士（医学）・甲第823号・令和4年3月15日; Copyright © 2021 Elsevier B.V. All rights reserved.; identifier:Atherosclerosis Vol.332 p.24-32 (2021 Sep); identifier:00219150; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4006; identifier:Atherosclerosis, 332: 24-32
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.atherosclerosis.2021.08.004
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4006/1/01%e7%94%b2823%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4006/2/02%e7%94%b2823%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4006/4/04%e7%94%b2823Suppl.01.pdf fulltext

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