Immunohistochemical Expression Status of p53, CD44v9, and Ki-67 in a Series of Fallopian Tube Lesions of High-grade Serous Carcinoma.

• Material Type: 博士論文
• Title: Immunohistochemical Expression Status of p53, CD44v9, and Ki-67 in a Series of Fallopian Tube Lesions of High-grade Serous Carcinoma.
• Author/Editor: Sugimoto, Sumire; Uchiyama, Tomoko; Kawahara, Naoki; Ohbayashi, Chiho; Kobayashi, Hiroshi
• Author Heading: Sugimoto, Sumire; Uchiyama, Tomoko; Kawahara, Naoki; Ohbayashi, Chiho; Kobayashi, Hiroshi
• Publication, Distribution, etc.: Lippincott Williams & Wilkins
• Publication Date: 2021-09
• Publication Date (W3CDTF): 2021-09
• Alternative Title: 高異型度漿液性癌における、卵管前癌病変のp53, CD44v9, Ki-67の免疫組織化学的発現態度
• Periodical title: International journal of gynecological pathology
• No. or year of volume/issue: 40 5
• Volume: 40
• Issue: 5
• Pages: 419-426
• ISSN (Periodical Title): ISSN : 0277-1691
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Dissertation Number: 甲第830号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: TP53; CD44v9; Ki-67; Serous tubal intraepithelial carcinoma (STIC); High-grade serous carcinoma (HGSC)
• Target Audience: 一般
• Note (General): type:Thesis; Pelvic high-grade serous carcinoma (HGSC) has been postulated to arise via a stepwise accumulation of (epi)genetic alterations from normal epithelium to secretory cell outgrowth (SCOUT), p53 signature, and serous tubal intraepithelial carcinoma (STIC) to invasive HGSC. The aim of this study is to investigate alterations in p53 and CD44v9 expression and the status of Ki-67 labeling index in a series of fallopian tube lesions of HGSC patients. A total of 45 specimens were analyzed in 16 patients with HGSC, and their lesions were categorized as follows: morphologically normal fallopian tube epithelium (FTE, n=6 samples), SCOUT (n=5), p53 signature (n=4), dormant STIC (n=8), active STIC (n=6), and HGSC (n=16). Morphologic features and immunohistochemical expression patterns of the p53 protein, CD44v9 protein, and Ki-67 antigen were blindly evaluated by 2 pathologists. Increased nuclear p53 protein accumulation was observed in p53 signature, dormant STIC, active STIC and HGSC compared with normal FTE and SCOUT (P<0.001). Immunohistochemistry scores of CD44v9 protein expression were significantly higher in normal FTE, SCOUT, and p53 signature than in dormant STIC, active STIC, and HGSC (P<0.001). Both active STIC and HGSC had significantly higher Ki-67 labeling indices than normal FTE, SCOUT, p53 signature and dormant STIC (P<0.001). CD44v9 loss contributes to the stepwise progression of p53 signature to dormant STIC. In conclusion, p53 mutation followed by CD44v9 loss may be involved in the evolution of STIC, which may confer positive clonal selection with a growth and survival advantage.; 博士（医学）・甲第830号・令和4年3月15日; Copyright © 2021 by the International Society of Gynecological Pathologists.; This article has been accepted for publication in International journal of gynecological pathology, 2021 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1097/PGP.0000000000000738.; 発行元が定める登録猶予期間終了の後、本文を登録予定（2022.09）; identifier:International journal of gynecological pathology Vol.40 No.5 p.419-426 (2021 Sep); identifier:02771691; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4013; identifier:International journal of gynecological pathology, 40(5): 419-426
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1097/pgp.0000000000000738
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4013/1/01%e7%94%b2830%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4013/2/02%e7%94%b2830%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

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