Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration.

• Material Type: 博士論文
• Title: Analysis focusing on plasma von Willebrand factor in pachychoroid neovasculopathy and age-related macular degeneration.
• Author/Editor: Hirai, Hiromasa; Yamashita, Mariko; Matsumoto, Masanori; Hayakawa, Masaki; Sakai, Kazuya; Ueda, Tetsuo; Ogata, Nahoko
• Author Heading: Hirai, Hiromasa; Yamashita, Mariko; Matsumoto, Masanori; Hayakawa, Masaki; Sakai, Kazuya; Ueda, Tetsuo; Ogata, Nahoko
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2021-10-07
• Publication Date (W3CDTF): 2021-10-07
• Alternative Title: Pachychoroid neovasculopathy と加齢黄斑変性症における血漿 von Willebrand 因子に焦点を当てた解析
• Periodical title: Scientific reports
• No. or year of volume/issue: 11 1
• Volume: 11
• Issue: 1
• Pages: Article No.19987-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Dissertation Number: 甲第832号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Diseases; Pathogenesis
• Target Audience: 一般
• Note (General): type:Thesis; Pachychoroid neovasculopathy (PNV) is a new concept of macular disorder. Some cases diagnosed as age-related macular degeneration (AMD) have been re-diagnosed as PNV. However, the biological features of PNV are still uncertain. The purpose of this study was to compare PNV and AMD by analyses focusing on von Willebrand factor (VWF) and complement factor H (CFH). Ninety-seven patients who were previously diagnosed with treatment naïve AMD were enrolled in this study. They were re-classified as either PNV or AMD based on the clinical criteria and 33 patients were classified as PNV and 64 patients as AMD. We examined the clinical data, analyzed VWF multimer and two genetic polymorphisms (I62V and Y402H) in the CFH. PNV group was significantly younger than AMD group (P = 0.001). In both I62V and Y402H, there were no significant differences between PNV and AMD while the recessive homozygous (AA) was found only in PNV group in I62V. The presence of unusually large VWF multimers (UL-VWFMs) and subretinal hemorrhages were significantly higher in PNV than in AMD (P = 0.045, P = 0.020, respectively). Thus, the residual UL-VWFMs may result in platelet thrombosis and hemorrhages in the choriocapillaris of PNV. In conclusion, our results suggest the biological differences between PNV and AMD.; 博士（医学）・甲第832号・令和4年3月15日; © 2021. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.; identifier:Scientific reports Vol.11 No.1 Article No.19987 (2021 Oct); identifier:20452322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4015; identifier:Scientific reports, 11(1): Article No.19987
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-021-99557-6
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4015/1/01%e7%94%b2832%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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