Ultrasound-detected synovitis of the forefoot in patients with early rheumatoid arthritis, unlike that of the hand, does not correlate positively with 28-joint disease activity scores.

• Material Type: 博士論文
• Title: Ultrasound-detected synovitis of the forefoot in patients with early rheumatoid arthritis, unlike that of the hand, does not correlate positively with 28-joint disease activity scores.
• Author/Editor: Hara, Ryota; Ozaki, Yusuke; Shimmyo, Naoki; Akai, Yasuhiro; Fujimoto, Takashi; Tanaka, Yasuhito
• Author Heading: Hara, Ryota; Ozaki, Yusuke; Shimmyo, Naoki; Akai, Yasuhiro; Fujimoto, Takashi; Tanaka, Yasuhito
• Publication, Distribution, etc.: 奈良医学会
• Publication Date: 2021-11-30
• Publication Date (W3CDTF): 2021-11-30
• Alternative Title: 早期関節リウマチ患者において関節エコーで検出される前足部滑膜炎は、手部滑膜炎とは異なり、28関節評価での疾患活動性スコアと正の相関を示さない
• Periodical title: Journal of Nara Medical Association
• No. or year of volume/issue: 72 4,5,6
• Volume: 72
• Issue: 4,5,6
• Pages: 51-59
• ISSN (Periodical Title): ISSN : 1345-0069
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Dissertation Number: 乙第1521号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: metatarsophalangeal joint; early rheumatoid arthritis; composite measure; ultrasound; synovitis
• Target Audience: 一般
• Note (General): type:Thesis; Objective : This study aimed to clarify the relationship between the ultrasound (US)-detected forefoot synovitis and systemic disease activity and functional disability in patients with early rheumatoid arthritis (ERA). Methods : Thirty-eight ERA patients (6 men, 32 women) prior to initiation of tight-control treatment were included. Semiquantitative US assessment for bilateral finger, wrist, and forefoot joints was conducted using gray-scale (GS) and power Doppler (PD), and each summation was defined as hand, foot, and total scores. The accuracy of US based on the physical examination for the metatarsophalangeal (MTP) joints was determined. The relationshio between each US score and composite measures using 28-joint counts, serum biomarkers, and patient-reported functional impairment scores was analyzed. Results : Based on MTP joint swelling and tenderness, for GS and PD scores ≥ 1, the positive predictive value was low (GS: 16.0%, 12.5%; PD: 38.5%, 17.5%). Hand US scores, especially in hand PD scores, showed a significant moderate positive correlation with disease activity scores and biomarkers; however, foot US scores showed no positive correlation with any factor. The results were robust in multivariate analyses that incorporated each score and were adjusted for age. Conclusions : US-detected forefoot synovitis may not be reflected in the composite disease activity scores not including direct forefoot assessment in ERA patients.; 博士（医学）・乙第1521号・令和4年3月15日; identifier:Journal of Nara Medical Association Vol.72 No.4,5,6 p.51-59 (2021.11); identifier:13450069; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4026; identifier:Journal of Nara Medical Association, 72(4,5,6): 51-59
• Access Restrictions: インターネット公開
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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