Orthostatic hemodynamics in the vertebral artery and blood pressure in patients with orthostatic dizziness/vertigo.

• Material Type: 博士論文
• Title: Orthostatic hemodynamics in the vertebral artery and blood pressure in patients with orthostatic dizziness/vertigo.
• Author/Editor: Matsumura, Yachiyo; Yamanaka, Toshiaki; Murai, Takayuki; Fujita, Nobuya; Kitahara, Tadashi
• Author Heading: Matsumura, Yachiyo; Yamanaka, Toshiaki; Murai, Takayuki; Fujita, Nobuya; Kitahara, Tadashi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2022-08
• Publication Date (W3CDTF): 2022-08
• Alternative Title: 起立性めまいにおける起立時の椎骨動脈血流動態と血圧の影響
• Periodical title: Auris Nasus Larynx
• No. or year of volume/issue: 49 4
• Volume: 49
• Issue: 4
• Pages: 593-598
• ISSN (Periodical Title): ISSN : 0385-8146
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Dissertation Number: 乙第1524号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Orthostatic dizziness/vertigo; Vertebral artery; Orthostatic hypotension; Extracranial doppler sonography
• Target Audience: 一般
• Note (General): type:Thesis; Objectives: Orthostatic dizziness/vertigo (ODV) is a common symptom and is believed to occur due to the cerebral hypoperfusion caused by orthostatic hypotension (OH). However, the detailed mechanism underlying ODV onset is poorly understood. The vertebral artery (VA) mainly supplies blood to the central vestibular system; therefore, the orthostatic decrease of VA blood flow could possibly lead to ODV. This study investigated the orthostatic blood pressure and VA hemodynamics in ODV patients to elucidate the hemodynamic mechanism underlying ODV onset. Furthermore, the influence of orthostatic hypotension (OH) on VA hemodynamics was examined because OH is probably the most common cause of ODV. Methods: This study included 181 patients with ODV and 73 control patients without ODV. All subjects underwent an active standing test to measure the extracranial Doppler (ECD) sonography spectrum of the VA and blood pressure (BP). VA blood flow velocity and BP were simultaneously measured for each patient in the supine static position and then in the upright standing positions following 3 min of standing. We investigated the orthostatic change in the average of flow velocity in bilateral VAs (VAFV) and BP for ODV patients compared with the control patients. Result: VAFV in ODV patients was significantly reduced when standing up compared with the control patients. In the ODV patients, there was no difference in orthostatic decrease in VAFV between patients those with OH and without OH. However, the VAFV in the standing position was significantly lower in patients with OH than without OH. In cases with OH, the ODV patients exhibited a greater decrease in VAFV compared with the control patients, but this was not statistically significant. In the absence of OH, a significantly greater orthostatic decrease in VAFV was observed in ODV patients compared with the controls. Conclusion: Our findings suggest that the orthostatic decrease of VA blood flow is deeply involved in the hemodynamic mechanism underlying ODV onset and is possibly associated with OH and other etiologies.; 博士（医学）・乙第1524号・令和4年3月15日; © 2021 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.; identifier:Auris Nasus Larynx Vol.49 No.4 p.593-598 (2022 Aug); identifier:03858146; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4029; identifier:Auris Nasus Larynx, 49(4): 593-598
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.anl.2021.12.002
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4029/1/01%e4%b9%991524%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4029/2/02%e4%b9%991524%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4029/3/03%e4%b9%991524%e6%9c%ac%e6%96%87.pdf fulltext