Efficacy of autogenous bone grafts preserved in 80% ethanol solution for preventing surgical site infection after cranioplasty: A retrospective cohort study.

• Material Type: 博士論文
• Title: Efficacy of autogenous bone grafts preserved in 80% ethanol solution for preventing surgical site infection after cranioplasty: A retrospective cohort study.
• Author/Editor: Kogeichi, Yohei; Motoyama, Yasushi; Takeshima, Yasuhiro; Matsuda, Ryosuke; Tamura, Kentaro; Nishimura, Fumihiko; Yamada, Shuichi; Nakagawa, Ichiro; Park, Young-Su; Fukushima, Hidetada; Nakase, Hiroyuki
• Author Heading: Kogeichi, Yohei; Motoyama, Yasushi; Takeshima, Yasuhiro; Matsuda, Ryosuke; Tamura, Kentaro; Nishimura, Fumihiko; Yamada, Shuichi; Nakagawa, Ichiro; Park, Young-Su; Fukushima, Hidetada; Nakase, Hiroyuki
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2022-06
• Publication Date (W3CDTF): 2022-06
• Alternative Title: 頭蓋骨形成術後の手術部位感染予防のための80％エタノール溶液に保存した自家骨移植片の有効性。後方視的コホート研究
• Periodical title: Interdisciplinary neurosurgery
• No. or year of volume/issue: 28
• Volume: 28
• Pages: Article No.101489-
• ISSN (Periodical Title): ISSN : 2214-7519
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-03-15
• Dissertation Number: 乙第1526号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Autogenous bone graft; Decompressive craniectomy; Ethanol; Surgical site infection
• Target Audience: 一般
• Note (General): type:Thesis; Background: Surgical site infection (SSI) is common following cranioplasty after decompressive craniectomy (DC). The aim of this study was to assess the risk of SSI following cranioplasty in terms of the preservation method of autogenous bone graft (ABG), comparing preservation in 80% ethanol versus the standard method of subcutaneous ABG preservation. Material and methods: The patients who underwent cranioplasty using ABGs after DC between 2008 and 2019 were retrospectively reviewed. SSIs were compared between patients whose ABG was preserved in 80% ethanol (group A) and those whose ABG was preserved subcutaneously (group B) using inverse probability of treatment weighting (IPTW) based on propensity scores to balance measurable confounders including elderly age, sex, expanded polytetrafluoroethylene, stroke, interval to cranioplasty, and diabetes mellitus. Results: Total number of 127 patients consisted of 56 in group A and 71 in group B. SSI after cranioplasty occurred in five patients each in groups A and B (8.9% vs. 7%, p = 0.748). IPTW analysis demonstrated that preservation in 80% ethanol was associated with a lower risk of SSI (odds ratio: 0.239, 95％ confidence interval: 0.0615–0.927, p = 0.039). Conclusion: The simple and less-invasive method of preserving ABGs in 80% ethanol for cranioplasty after DC might be potentially safe from an SSI perspective.; 博士（医学）・乙第1526号・令和4年3月15日; © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND licens(https://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Interdisciplinary neurosurgery Vol.28 Article No.101489 (2022 Jun); identifier:22147519; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4031; identifier:Interdisciplinary neurosurgery, 28: Article No.101489
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4031/1/01%e4%b9%991526%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4031/2/02%e4%b9%991526%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4031/3/03%e4%b9%991526%e6%9c%ac%e6%96%87.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.inat.2022.101489
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU