Protein C system in preterm babies with chronic lung disease: Prospective study.

• Material Type: 博士論文
• Title: Protein C system in preterm babies with chronic lung disease: Prospective study.
• Author/Editor: Kamamoto, Tomoyuki; Nakajima, Yuto; Uchida, Yumiko; Nakagawa, Takashi; Tonegawa, Hitoshi; Tani, Yuki; Nishimoto, Eri; Takahashi, Yukihiro; Nishikubo, Toshiya; Nogami, Keiji
• Author Heading: Kamamoto, Tomoyuki; Nakajima, Yuto; Uchida, Yumiko; Nakagawa, Takashi; Tonegawa, Hitoshi; Tani, Yuki; Nishimoto, Eri; Takahashi, Yukihiro; Nishikubo, Toshiya; Nogami, Keiji
• Publication, Distribution, etc.: Wiley
• Publication Date: 2022-01
• Publication Date (W3CDTF): 2022-01
• Alternative Title: 慢性肺疾患の早産児におけるプロテインC経路 : 前向き研究
• Periodical title: Pediatrics international
• No. or year of volume/issue: 64 1
• Volume: 64
• Issue: 1
• Pages: Article No.e15221-
• ISSN (Periodical Title): ISSN : 1328-8067
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2022-09-28
• Dissertation Number: 甲第850号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: anticoagulant factor; inflammation; mechanical ventilation; thrombomodulin; very low birth weight infants
• Target Audience: 一般
• Note (General): type:Thesis; Background: Chronic lung disease (CLD) is a major neonatal pulmonary disorder associated with inflammation. Recent studies have shown that protein C anticoagulant pathways, such as those for protein C (PC), protein S (PS), and thrombomodulin (TM), could be useful indices for reflecting pulmonary injury. However, the involvement of these factors in preterm infants with very low birthweight (VLBW) who have developed CLD remains to be investigated. Here, we investigated whether PC pathway-related factors could predict the development of CLD in preterm infants with VLBW. Methods: We collected plasma samples from 26 preterm infants with VLBW (13 each from those with and without CLD) at the time of birth and measured TM, PC, and PS levels in their plasmas. We analyzed prospectively the relationship between these factors in infants with and without CLD. Results: There were significant differences in gestational age, birthweight, Apgar score (5 min), and duration of mechanical ventilation between the CLD and non-CLD groups. No significant differences in the PC and PS levels at birth were observed between the two groups, whereas the TM levels in the CLD group were significantly higher than those in the non-CLD group (P = 0.013). The TM levels correlated with gestational age and duration of mechanical ventilation. However, covariance analysis demonstrated that gestational age was significantly associated with TM levels, and consequently, development of CLD was not associated with TM level at birth. Conclusions: Thrombomodulin, PC, and PS levels at birth could not predict the development of CLD in preterm infants with VLBW.; 博士（医学）・甲第850号・令和4年9月28日; © 2022 Japan Pediatric Society.; This is the peer reviewed version of the following article: [https://onlinelibrary.wiley.com/doi/10.1111/ped.15221], which has been published in final form at [https://doi.org/10.1111/ped.15221]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.; 発行元が定める登録猶予期間終了の後、本文を登録予定（2023.01）; identifier:Pediatrics international Vol.64 No.1 Article No.e15221 (2022 Jan); identifier:13288067; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4077; identifier:Pediatrics international, 64(1): Article No.e15221
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1111/ped.15221
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4077/1/01%e7%94%b2850%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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