Serum Free Radical Scavenging Capacity Profiles of Patients with Chronic Obstructive Pulmonary Disease

• Material Type: 博士論文
• Title: Serum Free Radical Scavenging Capacity Profiles of Patients with Chronic Obstructive Pulmonary Disease
• Author/Editor: Sakaguchi, Kazuhiro; Yoshikawa, Masanori; Fujita, Yukio; Yamamoto, Yoshifumi; Ibaraki, Takahiro; Fujioka, Nobuhiro; Osa, Takao; Yamauchi, Motoo; Ichikawa, Hiroshi; Muro, Shigeo
• Author Heading: Sakaguchi, Kazuhiro; Yoshikawa, Masanori; Fujita, Yukio; Yamamoto, Yoshifumi; Ibaraki, Takahiro; Fujioka, Nobuhiro; Osa, Takao; Yamauchi, Motoo; Ichikawa, Hiroshi; Muro, Shigeo
• Publication, Distribution, etc.: Dove Medical Press Limited
• Publication Date: 2023
• Publication Date (W3CDTF): 2023
• Alternative Title: 慢性閉塞性肺疾患患者における血清フリーラジカル消去活性能の評価
• Periodical title: International Journal of Chronic Obstructive Pulmonary Disease
• No. or year of volume/issue: 18
• Volume: 18
• Pages: 615-624
• ISSN (Periodical Title): ISSN : 1178-2005
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2023-09-29
• Dissertation Number: 甲第890号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: oxidative stress; free radicals; the multiple free-radical scavenging method; pathophysiology; exacerbations, prognosis
• Target Audience: 一般
• Note (General): type:Thesis; Background: Oxidative stress is an important mechanism for the development and progression of chronic obstructive pulmonary disease (COPD). It may also contribute to systemic manifestation in patients with COPD. Reactive oxygen species (ROS) including free radicals play a crucial role in oxidative stress in COPD. The aims of this study were to determine serum scavenging capacity profile against multiple free radicals and to evaluate its correlation with pathophysiology, exacerbations, and prognosis in patients with COPD. Methods: Serum scavenging capacity profile against multiple free radicals comprising hydroxyl radical (•OH), superoxide radical (O2−•), alkoxy radical (RO•), methyl radical (•CH3), alkylperoxyl radical (ROO•), and singlet oxygen (1O2) was assessed using the multiple free-radical scavenging method in 37 patients with COPD (mean age, 71 years; mean forced expiratory volume in 1 s, 55.2% predicted). The severity of emphysema was evaluated by Goddard classification on chest computed tomography. Exacerbations were recorded prospectively for 1 year and the overall mortality was assessed 5 years after the initial assessment. Results: •OH scavenging capacity was significantly decreased (p < 0.05) and O2−• and •CH3 scavenging capacity tended to decrease in patients with COPD compared to that in healthy controls. On the other hand, ROO• scavenging capacity tended to increase. In addition, RO• scavenging capacity was associated with severity of emphysema (p < 0.05) and exacerbation frequency (p < 0.02). There was a difference in the profile of the scavenging capacity between survived and deceased patients with COPD for 5 years after initial assessment. Conclusion: Characteristic profile of free radical scavenging capacity can provide insight into the pathophysiology and prognosis of patients with COPD.; 権利情報：© 2023 Sakaguchi et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).; identifier:International Journal of Chronic Obstructive Pulmonary Disease. 2023, vol.18, p.615-624; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4220; identifier:International Journal of Chronic Obstructive Pulmonary Disease, 18: 615-624
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.2147/COPD.S385780
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

Table of Contents

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4220/1/K890%20full.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4220/2/K890_abstract.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4220/3/K890_review.pdf fulltext