Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction

• Material Type: 博士論文
• Title: Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction
• Author/Editor: Hashimoto, Yukihiro; Soeda, Tsunenari; Seno, Ayako; Okayama, Satoshi; Fukuda, Nozomi; Yano, Hiroki; Iwai, Atsushi; Nogi, Kazutaka; Hirai, Kaeko; Fujimoto, Hajime; Suzuki, Megumi; Iwama, Hajime; Nakai, Takehito; Doi, Naofumi; Saito, Yoshihiko
• Author Heading: Hashimoto, Yukihiro; Soeda, Tsunenari; Seno, Ayako; Okayama, Satoshi; Fukuda, Nozomi; Yano, Hiroki; Iwai, Atsushi; Nogi, Kazutaka; Hirai, Kaeko; Fujimoto, Hajime; Suzuki, Megumi; Iwama, Hajime; Nakai, Takehito; Doi, Naofumi; Saito, Yoshihiko
• Publication, Distribution, etc.: Japanese Circulation Society
• Publication Date: 2022-11-25
• Publication Date (W3CDTF): 2022-11-25
• Alternative Title: 再灌流後急性心筋梗塞患者におけるリバースリモデリングと非造影T1低信号梗塞コア
• Periodical title: Circulation journal
• No. or year of volume/issue: 86 12
• Volume: 86
• Issue: 12
• Pages: 1968-1979
• ISSN (Periodical Title): ISSN : 1346-9843
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2023-03-15
• Dissertation Number: 乙第1529号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Acute myocardial infarction; Cardiac magnetic resonance imaging; Native T1 mapping; Reverse remodeling; T1 hypointense infarct core
• Target Audience: 一般
• Note (General): type:Thesis; Background: Non-contrast T1 hypointense infarct cores (ICs) within infarcted myocardium detected using cardiac magnetic resonance imaging (CMR) T1 mapping may help assess the severity of left ventricular (LV) injury. However, because the relationship of ICs with chronic LV reverse remodeling (LVRR) is unknown, this study aimed to clarify it. Methods and Results: We enrolled patients with reperfused AMI who underwent baseline CMR on day-7 post-primary percutaneous coronary intervention (n=109) and 12-month follow-up CMR (n=94). Correlations between ICs and chronic LVRR (end-systolic volume decrease ≥15% at 12-month follow-up from baseline CMR) were investigated. We detected 52 (47.7%) ICs on baseline CMR by non-contrast-T1 mapping. LVRR was found in 52.1% of patients with reperfused AMI at 12-month follow-up. Patients with ICs demonstrated higher peak creatine kinase levels, higher B-type natriuretic peptide levels at discharge, lower LV ejection fraction at discharge, and lower incidence of LVRR than those without ICs (26.5% vs. 73.3%, P<0.001) at follow-up. Multivariate logistic regression analysis showed that the presence of ICs was an independent and the strongest negative predictor for LVRR at 12-month followup (hazard ratio: 0.087, 95% confidence interval: 0.017–0.459, P=0.004). Peak creatine kinase levels, native T1 values at myocardial edema, and myocardial salvaged indices also correlated with ICs. Conclusions: ICs detected by non-contrast-T1 mapping with 3.0-T CMR were an independent negative predictor of LVRR in patients with reperfused AMI.; 博士（医学）・乙第1529号・令和5年3月15日; © 2022, THE JAPANESE CIRCULATION SOCIETY This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.; identifier:Circulation journal Vol.86 No.12 p.1968-1979 (2022 Nov); identifier:13469843; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4114; identifier:Circulation journal, 86(12): 1968-1979
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1253/circj.CJ-22-0479
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4114/1/01%e4%b9%991529%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

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