Differentiation of embryonic stem cells into lung-like cells using lung-derived matrix sheets

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Differentiation of embryonic stem cells into lung-like cells using lung-derived matrix sheets

Material type: 博士論文

Author: Kitamura, Tomotakaほか

Publisher: Elsevier Inc.

Publication date: 2023-12

Material Format: Digital

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Name of awarding university/degree: 奈良県立医科大学,博士（医学）

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Note (General)：: type:ThesisVarious extracellular matrix (ECM) in the lungs regulate tissue development and homeostasis, as well as provide support for cell structures...

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Material Type: 博士論文
Title: Differentiation of embryonic stem cells into lung-like cells using lung-derived matrix sheets
Author/Editor: Kitamura, Tomotaka
Misu, Masayasu
Yoshikawa, Masahide
Ouji, Yukiteru
Author Heading: Kitamura, Tomotaka
Misu, Masayasu
Yoshikawa, Masahide
Ouji, Yukiteru
Publication, Distribution, etc.: Elsevier Inc.
Publication Date: 2023-12
Publication Date (W3CDTF): 2023-12
Alternative Title: 肺由来脱細胞化マトリックスシートを用いた ES 細胞から肺細胞への分化誘導
Periodical title: Biochemical and Biophysical Research Communications
No. or year of volume/issue: 686
Volume: 686
Pages: 149197-
ISSN (Periodical Title): ISSN : 0006-291X
Degree grantor/type: 奈良県立医科大学
Date Granted: 2024-03-14
Dissertation Number: 甲第904号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: extracellular matrix
stem cell
matrix sheets
differentiation
lung
Target Audience: 一般
Note (General): type:Thesis
Various extracellular matrix (ECM) in the lungs regulate tissue development and homeostasis, as well as provide support for cell structures. However, few studies regarding the effects of lung cell differentiation using lung-derived ECM (LM) alone have been reported. The present study investigated the capability of lung-derived matrix sheets (LMSs) to induce lung cell differentiation using mouse embryonic stem (ES) cells. Expressions of lung-related cell markers were significantly upregulated in ES-derived embryoid bodies (EBs) cultured on an LMS for two weeks. Moreover, immunohistochemical analysis of EBs grown on LMSs revealed differentiation of various lung-related cells. These results suggest that an LMS can be used to promote differentiation of stem cells into lung cells.
権利情報：© 2023 Elsevier Inc. All rights reserved.
identifier:Biochemical and Biophysical Research Communications. 2023 Dec, vol.686, article no.149197
identifier:0006-291X
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4355
identifier:Biochemical and Biophysical Research Communications, 686: 149197
Source: fulltext
http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4355/1/01%e7%94%b2904%e6%9c%ac%e6%96%87.pdf
fulltext
http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4355/2/02%e7%94%b2904%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf
fulltext
http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4355/3/03%e7%94%b2904%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
Access Restrictions: インターネット公開
Related Material (DOI): 10.1016/j.bbrc.2023.149197
Periodical Title (NCID): AA00564395
https://ci.nii.ac.jp/ncid/AA00564395
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU