Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan

• Material Type: 博士論文
• Title: Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan
• Author/Editor: Fujikura, Hiroyuki; Chang, Bin; Tamura, Kosuke; Watanabe, Hiroshi; Tanabe, Yoshinari; Kuronuma, Koji; Fujita, Jiro; Oshima, Kengo; Maruyama, Takaya; Abe, Shuichi; Kasahara, Kei; Nishi, Junichiro; Kubota, Tetsuya; Kinjo, Yuki; Serizawa, Yusuke; Shimbashi, Reiko; Fukusumi, Munehisa; Shimada, Tomoe; Sunagawa, Tomimasa; Suzuki, Motoi; Oishi, Kazunori; Adult IPD Study Group
• Author Heading: Fujikura, Hiroyuki; Chang, Bin; Tamura, Kosuke; Watanabe, Hiroshi; Tanabe, Yoshinari; Kuronuma, Koji; Fujita, Jiro; Oshima, Kengo; Maruyama, Takaya; Abe, Shuichi; Kasahara, Kei; Nishi, Junichiro; Kubota, Tetsuya; Kinjo, Yuki; Serizawa, Yusuke; Shimbashi, Reiko; Fukusumi, Munehisa; Shimada, Tomoe; Sunagawa, Tomimasa; Suzuki, Motoi; Oishi, Kazunori; Adult IPD Study Group
• Publication, Distribution, etc.: Nature Portfolio
• Publication Date: 2022-02
• Publication Date (W3CDTF): 2022-02
• Alternative Title: 日本における小児PCV13導入後2014年-2018年の成人肺炎球菌性髄膜炎
• Periodical title: Scientific Reports
• No. or year of volume/issue: 12 1
• Volume: 12
• Issue: 1
• Pages: 3066-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-03-14
• Dissertation Number: 甲第899号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Diseases; Medical research; Microbiology
• Target Audience: 一般
• Note (General): type:Thesis; We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65).; 権利情報：© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.; identifier:Scientific Reports. 2022 Feb, vol.12, no.1, article no.3066; identifier:2045-2322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4350; identifier:Scientific Reports, 12(1): 3066
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-022-06950-w
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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