Synergistic effect of proteinuria on dipstick hematuria-related decline in kidney function: The Japan Specific Health Checkups (J-SHC) Study

• Material Type: 博士論文
• Title: Synergistic effect of proteinuria on dipstick hematuria-related decline in kidney function: The Japan Specific Health Checkups (J-SHC) Study
• Author/Editor: Tasaki, Hikari; Eriguchi, Masahiro; Yoshida, Hisako; Uemura, Takayuki; Fukata, Fumihiro; Nishimoto, Masatoshi; Kosugi, Takaaki; Matsui, Masaru; Samejima, Ken-Ichi; Iseki, Kunitoshi; Asahi, Koichi; Yamagata, Kunihiro; Konta, Tsuneo; Fujimoto, Shouichi; Narita, Ichiei; Kasahara, Masato; Shibagaki, Yugo; Moriyama, Toshiki; Kondo, Masahide; Watanabe, Tsuyoshi; Tsuruya, Kazuhiko
• Author Heading: Tasaki, Hikari; Eriguchi, Masahiro; Yoshida, Hisako; Uemura, Takayuki; Fukata, Fumihiro; Nishimoto, Masatoshi; Kosugi, Takaaki; Matsui, Masaru; Samejima, Ken-Ichi; Iseki, Kunitoshi; Asahi, Koichi; Yamagata, Kunihiro; Konta, Tsuneo; Fujimoto, Shouichi; Narita, Ichiei; Kasahara, Masato; Shibagaki, Yugo; Moriyama, Toshiki; Kondo, Masahide; Watanabe, Tsuyoshi; Tsuruya, Kazuhiko
• Publication, Distribution, etc.: Springer
• Publication Date: 2023-12
• Publication Date (W3CDTF): 2023-12
• Alternative Title: 特定健診受診者を対象とした血尿に関連した腎機能低下に対する蛋白尿の相乗的な影響についての検証
• Periodical title: Clinical and Experimental Nephrology
• No. or year of volume/issue: 27 12
• Volume: 27
• Issue: 12
• Pages: 990-1000
• ISSN (Periodical Title): ISSN : 1342-1751
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-03-14
• Dissertation Number: 甲第908号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: eGFR Decline; Hematuria; Proteinuria; Sex differences
• Target Audience: 一般
• Note (General): type:Thesis; Background: The effect of isolated hematuria without proteinuria on kidney function decline, and the modification by the severity of proteinuria in general population are not fully elucidated. Methods: Participants were included in the Japan Specific Health Checkups Study between 2008 and 2014. The exposure of interest was the frequency of dipstick hematuria during the observation. In each proteinuria frequency category (non-, occasional, persistent), hematuria-related decline in the eGFR rate was examined by analysis of covariance (ANCOVA). eGFR decline trajectories were also assessed using mixed-effects models. Results: Among the 552,951 participants, 146,753 (26.5%) had hematuria, and 56,021 (10.1%) and 8,061 (1.5%) had occasional and persistent proteinuria, respectively. During the median follow-up of 3.0 years, annual change in eGFR decline in participants with hematuria was significantly faster than in those without hematuria (mean [95% confidence interval]: - 0.95 [- 0.98 to - 0.92] vs - 0.86 [- 0.87 to - 0.84] mL/min/1.73 m2/year; P < 0.001). In ANCOVA, the hematuria-related annual eGFR decline rate increased as proteinuria frequency categories increased (differences in annual eGFR decline rate between participants with and without hematuria: 0.08 [0.06 to 0.09] in participants with non-proteinuria category, 0.17 [0.15 to 0.18] in occasional proteinuria category, and 0.68 [0.65 to 0.71] mL/min/1.73 m2/year in persistent proteinuria category; P for interaction < 0.001). Similar results were obtained by the linear mixed-effect model. Conclusions: Proteinuria has a synergistic effect on dipstick hematuria-related decline in kidney function. Among the general population without proteinuria throughout the observational period, the "isolated hematuria"-related eGFR decline was statistically significant but the difference was small.; 権利情報：© The Author(s), under exclusive licence to Japanese Society of Nephrology 2023. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10157-023-02390-6; identifier:Clinical and Experimental Nephrology. 2023 Dec, vol.27, no.12, p.990-1000; identifier:1342-1751; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4359; identifier:Clinical and Experimental Nephrology, 27(12): 990-1000
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4359/1/01%e7%94%b2908%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4359/2/02%e7%94%b2908%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4359/3/03%e7%94%b2908%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4359/4/04%e7%94%b2908Figure.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4359/5/05%e7%94%b2908Supplemental%20materials.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1007/s10157-023-02390-6
• Periodical Title (NCID): AA11126935; https://ci.nii.ac.jp/ncid/AA11126935
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU