Pediatric mesangial proliferative glomerulonephritis has increased the platelet thrombus formation potentials under high-shear flow condition

• Material Type: 博士論文
• Title: Pediatric mesangial proliferative glomerulonephritis has increased the platelet thrombus formation potentials under high-shear flow condition
• Author/Editor: Omae, Takashi; Ishikawa, Tomoaki; Ogiwara, Kenichi; Nogami, Keiji
• Author Heading: Omae, Takashi; Ishikawa, Tomoaki; Ogiwara, Kenichi; Nogami, Keiji
• Publication, Distribution, etc.: Karger
• Publication Date: 2024
• Publication Date (W3CDTF): 2024
• Alternative Title: 小児メサンギウム増殖性糸球体腎炎ではhigh-shear血流条件下で血小板血栓形成能が亢進する
• Periodical title: Nephron
• No. or year of volume/issue: 148 6
• Volume: 148
• Issue: 6
• Pages: 415-425
• ISSN (Periodical Title): ISSN : 1660-8151
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-03-14
• Dissertation Number: 甲第921号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Children; flow chamber system; mesangial proliferative glomerulonephritis; platelet thrombus formation; whole blood
• Target Audience: 一般
• Note (General): type:Thesis; Introduction: Blood coagulation is associated with glomerulonephritis (GN) pathophysiology. Using whole-blood-based rotational thromboelastometry, we recently reported that the degree of hypercoagulability in pediatric patients with immunoglobulin A nephropathy (IgAN), a GN, might be associated with pathological severity. To further clarify the coagulation status of mesangial proliferative glomerulonephritis (MesPGN), we assessed the platelet thrombus fonnation (PTF) under high-shear flow using a microchip-based flow chamber system (T-TAS®). Methods: Thirty-four pediatric patients definitively diagnosed with MesPGN by renal biopsy at Nara Medical University Hospital between 2015 and 2022 were enrolled, and 29 patients (case group; median age, 8.0 years) were assessed. Microchips coated with collagen (PL-chip) were used to assess PTF at high-shear in whole blood. The times to increase by 10 and 30 kPa (T10 and T3o) from baseline were calculated and compared with those of the pediatric controls. Changes in the parameters during the treatment course and the relationship between pathological severity and the parameters were evaluated. Results: T10 and T3o parameters in the PL-chip were significantly shorter and the area under the curves were greater in the case group than those in the control group (both p <0.05). Each parameter was enhanced during the 3-week treatment but improved after the end of treatment. No significant relationship was observed between pathological severity and these parameters. Little PTF difference was observed between IgAN and Henoch-Schonlein purpura nephritis. Conclusions: Pediatric MesPGN increased the potential for PTF under high-shear flow conditions.; 権利情報：This is the accepted manuscript version of an article published by Karger Publishers in [Nephron /2024/148(6)/415-425 DOI: 10.1159/000534494] and available on https://doi.org/10.1159/000534494; identifier:Nephron. 2024, vol.148, no.6, p.415-425; identifier:1660-8151; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4372; identifier:Nephron, 148(6): 415-425
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4372/1/01%e7%94%b2921%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4372/2/02%e7%94%b2921%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4372/3/03%e7%94%b2921%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1159/000534494
• Periodical Title (NCID): AA1278405X; https://ci.nii.ac.jp/ncid/AA1278405X
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU