Machine learning-based analysis of regional differences in out-of-hospital cardiopulmonary arrest outcomes and resuscitation interventions in Japan

• Material Type: 博士論文
• Title: Machine learning-based analysis of regional differences in out-of-hospital cardiopulmonary arrest outcomes and resuscitation interventions in Japan
• Author/Editor: Kawai, Yasuyuki; Yamamoto, Koji; Miyazaki, Keita; Asai, Hideki; Fukushima, Hidetada
• Author Heading: Kawai, Yasuyuki; Yamamoto, Koji; Miyazaki, Keita; Asai, Hideki; Fukushima, Hidetada
• Publication, Distribution, etc.: Nature Portfolio
• Publication Date: 2023-09
• Publication Date (W3CDTF): 2023-09
• Alternative Title: 日本における院外心肺停止の予後と蘇生介入の地域差に関する機械学習ベースの分析
• Periodical title: Scientific Reports
• No. or year of volume/issue: 13 1
• Volume: 13
• Issue: 1
• Pages: 15884-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-03-14
• Dissertation Number: 甲第925号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Medical research; Therapeutics
• Target Audience: 一般
• Note (General): type:Thesis; Refining out-of-hospital cardiopulmonary arrest (OHCA) resuscitation protocols for local emergency practices is vital. The lack of comprehensive evaluation methods for individualized protocols impedes targeted improvements. Thus, we employed machine learning to assess emergency medical service (EMS) records for examining regional disparities in time reduction strategies. In this retrospective study, we examined Japanese EMS records and neurological outcomes from 2015 to 2020 using nationwide data. We included patients aged ≥ 18 years with cardiogenic OHCA and visualized EMS activity time variations across prefectures. A five-layer neural network generated a neurological outcome predictive model that was trained on 80% of the data and tested on the remaining 20%. We evaluated interventions associated with changes in prognosis by simulating these changes after adjusting for time factors, including EMS contact to hospital arrival and initial defibrillation or drug administration. The study encompassed 460,540 patients, with the model's area under the curve and accuracy being 0.96 and 0.95, respectively. Reducing transport time and defibrillation improved outcomes universally, while combining transport time and drug administration showed varied efficacy. In conclusion, the association of emergency activity time with neurological outcomes varied across Japanese prefectures, suggesting the need to set targets for reducing activity time in localized emergency protocols.; 権利情報：© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.; identifier:Scientific Reports. 2023 Sep, vol.13, no.1, article no.15884; identifier:2045-2322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4376; identifier:Scientific Reports, 13(1): 15884
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-023-43210-x
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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