Molecular mechanism of formation and destruction of a pseudo‑capsule in clear cell renal cell carcinoma

• Material Type: 博士論文
• Title: Molecular mechanism of formation and destruction of a pseudo‑capsule in clear cell renal cell carcinoma
• Author/Editor: Shimizu, Takuto; Miyake, Makito; Iida, Kota; Onishi, Sayuri; Fujii, Tomomi; Iemura, Yusuke; Ichikawa, Kazuki; Omori, Chihiro; Maesaka, Fumisato; Tomizawa, Mitsuru; Miyamoto, Tatsuki; Tanaka, Nobumichi; Fujimoto, Kiyohide
• Author Heading: Shimizu, Takuto; Miyake, Makito; Iida, Kota; Onishi, Sayuri; Fujii, Tomomi; Iemura, Yusuke; Ichikawa, Kazuki; Omori, Chihiro; Maesaka, Fumisato; Tomizawa, Mitsuru; Miyamoto, Tatsuki; Tanaka, Nobumichi; Fujimoto, Kiyohide
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2024-03
• Publication Date (W3CDTF): 2024-03
• Alternative Title: 淡明腎細胞癌における偽被膜の形成および破綻の分子学的機序
• Periodical title: Oncology letters
• No. or year of volume/issue: 27 5
• Volume: 27
• Issue: 5
• Pages: 225-
• ISSN (Periodical Title): ISSN : 1792-1082
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-06-26
• Dissertation Number: 甲第931号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: RCC; PC; prognostic factor; molecular mechanism; rat model
• Target Audience: 一般
• Note (General): type:Thesis; The process and molecular mechanisms underlying the formation and destruction of a pseudo-capsule (PC) in clear cell renal cell carcinoma (ccRCC) are poorly understood. In the present study, the PCs of surgical specimens from primary tumors and metastatic lesions in 169 patients with ccRCC, and carcinogen-induced ccRCC rat models were semi-quantified using the invasion of PC (i-Cap) score system. This was based on the relationship among the tumor, PC and adjacent normal tissue (NT) as follows: i-Cap 0, tumor has no PC and does not invade NT; i-Cap 1, tumor has a complete PC and does not invade into the PC; i-Cap 2, tumor with focal absences in the PC, which partially invades the PC but not completely through the PC; i-Cap 3, tumor crosses the PC and invades the NT; i-Cap 4, tumor directly invades the NT without a PC. The study suggested that PC formation was not observed without physical compression, and also revealed that tumor invasion into the PC was a prognostic factor for postoperative oncological outcomes. Higher i-Cap, Fuhrman grade and tumor size were independent poor prognostic factors for postoperative disease-free survival. mRNA expression arrays generated from carcinogen-induced ccRCC rat models were used to explore genes potentially associated with the formation and destruction of a PC. Subsequently, human ccRCC specimens were validated for four genes identified via expression array; the results revealed that collagen type 4A2, matrix metalloproteinase-7 and l-selectin were upregulated alongside the progression of i-Cap score. Conversely, endoglin was downregulated. In conclusion, the present study provides insights into the formation and destruction of a PC, and the results may aid the treatment and management of patients with ccRCC.; 権利情報：© 2024 Shimizu et al. This is an open access article distributed under the terms of Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Oncology letters. 2024 Mar, vol.27, no.5, article no.225; identifier:1792-1082; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4388; identifier:Oncology letters, 27(5): 225
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4388/1/01%e7%94%b2931%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4388/2/02%e7%94%b2931%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4388/3/03%e7%94%b2931%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.3892/ol.2024.14358
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU