The Combination of the Lactate Dehydrogenase/Hemoglobin Ratio with the PLASMIC Score Facilitates Differentiation of TTP from Septic DIC Without Identification of Schistocytes

• Material Type: 博士論文
• Title: The Combination of the Lactate Dehydrogenase/Hemoglobin Ratio with the PLASMIC Score Facilitates Differentiation of TTP from Septic DIC Without Identification of Schistocytes
• Author/Editor: Nishimura, Nobushiro; Yoshimoto, Kiyomi; Yada, Noritaka; Kakiwaki, Ayaka; Sawa, Akihiro; Senzaki, Satoshi; Kawashima, Hiromasa; Yoneima, Ryo; Ono, Shiro; Sakai, Kazuya; Matsumoto, Masanori; Fukushima, Hidetada; Nishio, Kenji
• Author Heading: Nishimura, Nobushiro; Yoshimoto, Kiyomi; Yada, Noritaka; Kakiwaki, Ayaka; Sawa, Akihiro; Senzaki, Satoshi; Kawashima, Hiromasa; Yoneima, Ryo; Ono, Shiro; Sakai, Kazuya; Matsumoto, Masanori; Fukushima, Hidetada; Nishio, Kenji
• Publication, Distribution, etc.: SAGE Publications
• Publication Date: 2023-10
• Publication Date (W3CDTF): 2023-10
• Alternative Title: LD/Hb比をPLASMICスコアと一緒に使用することで、破砕赤血球の識別なしにTTPと敗血症性DICの区別が容易になる
• Periodical title: Clinical and applied thrombosis/hemostasis
• No. or year of volume/issue: 29
• Volume: 29
• Pages: 10760296231207600-
• ISSN (Periodical Title): ISSN : 1076-0296
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-06-26
• Dissertation Number: 甲第933号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: LD/Hb ratio; PLASMIC score; TTP; sepsis‌; septic DIC
• Target Audience: 一般
• Note (General): type:Thesis; In some cases, differentiating thrombotic thrombocytopenic purpura (TTP) from septic disseminated intravascular coagulation (DIC) without measuring ADAMTS13 activity is critical for urgent lifesaving plasma exchange. To investigate whether PLASMIC score without identifying the presence of schistocytes, D-dimer, fibrin/fibrinogen degradation products (FDP), FDP/D-dimer ratio, prothrombin time-international normalized ratio (PT-INR), lactate dehydrogenase (LD), hemoglobin (Hb), and LD/Hb ratio are useful in differentiating patients with TTP from those with septic DIC. Retrospective analysis was conducted on the medical records of the patients with septic DIC (32 patients) or TTP (16 patients). The PLASMIC score and other laboratory measurements all were helpful in differentiating TTP from septic DIC. When dichotomized between high risk (scores 6-7) and intermediate-low risk (scores 0-5), the PLASMIC score predicted TTP with a sensitivity of 75.0% and a specificity of 100%. However, 4 of 16 patients with TTP and 19 of 32 patients with septic DIC showed comparable PLASMIC scores of 4 or 5, making it difficult to distinguish between the two by PLASMIC score alone. Among the measurements examined, the LDH/Hb ratio was the most useful for differentiation. Receiver operating characteristic analysis of the LD/Hb ratio for predicting TTP revealed a cutoff of 53.7 (IU/10 g) (sensitivity 0.94, specificity 0.91). If the LD/Hb ratio was less than 53.7, it was unlikely that the patient had TTP. A combination of the LD/Hb ratio and the PLASMIC score may be useful for distinguishing between TTP and DIC and identifying patients who need rapid plasma exchange or caplacizumab administration.; 権利情報：Nishimura N, et al. The Combination of the Lactate Dehydrogenase/Hemoglobin Ratio with the PLASMIC Score Facilitates Differentiation of TTP from Septic DIC Without Identification of Schistocytes. Clinical and Applied Thrombosis-Hemostasis. 2023. 29:10760296231207629. Copyright © The Author(s) 2023. doi: 10.1177/10760296231207629; identifier:Clinical and applied thrombosis/hemostasis. 2023 Oct, vol.29, article no.10760296231207600; identifier:1076-0296; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4390; identifier:Clinical and applied thrombosis/hemostasis, 29: 10760296231207600
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4390/1/01%e7%94%b2933%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4390/2/02%e7%94%b2933%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4390/3/03%e7%94%b2933%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1177/10760296231207629
• Periodical Title (NCID): AA11016631; https://ci.nii.ac.jp/ncid/AA11016631
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU