Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction

• Material Type: 博士論文
• Title: Prognostic impact and predictors of persistent renal dysfunction in acute kidney injury after percutaneous coronary intervention for acute myocardial infarction
• Author/Editor: Nakamura, Takuya; Watanabe, Makoto; Sugiura, Junichi; Kyodo, Atsushi; Nobuta, Saki; Nogi, Kazutaka; Nakada, Yasuki; Ishihara, Satomi; Hashimoto, Yukihiro; Nakagawa, Hitoshi; Ueda, Tomoya; Seno, Ayako; Nishida, Taku; Onoue, Kenji; Hikoso, Shungo
• Author Heading: Nakamura, Takuya; Watanabe, Makoto; Sugiura, Junichi; Kyodo, Atsushi; Nobuta, Saki; Nogi, Kazutaka; Nakada, Yasuki; Ishihara, Satomi; Hashimoto, Yukihiro; Nakagawa, Hitoshi; Ueda, Tomoya; Seno, Ayako; Nishida, Taku; Onoue, Kenji; Hikoso, Shungo
• Publication, Distribution, etc.: Nature Portfolio
• Publication Date: 2024-03
• Publication Date (W3CDTF): 2024-03
• Alternative Title: 急性心筋梗塞に対する経皮的冠動脈インターベンション後の急性腎障害において腎機能障害の持続が予後へ与える影響とその予測因子について
• Periodical title: Scientific Reports
• No. or year of volume/issue: 14 1
• Volume: 14
• Issue: 1
• Pages: 6299-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-09-27
• Dissertation Number: 甲第936号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Cardiology; Nephrology
• Target Audience: 一般
• Note (General): type:Thesis; This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 877 patients who underwent emergency PCI for AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.3 mg/dL or ≥ 50% from baseline within 48 h after PCI. Persistent AKI was defined as residual impairment of SCr ≥ 0.3 mg/dL or ≥ 50% from baseline 1 month after the procedure. The primary outcome was the composite endpoints of death, myocardial infarction, hospitalization for heart failure, stroke, and dialysis. AKI and persistent AKI were observed in 82 (9.4%) and 25 (2.9%) patients, respectively. Multivariate Cox proportional hazards analysis demonstrated that persistent AKI, but not transient AKI, was an independent predictor of primary outcome (hazard ratio, 4.99; 95% confidence interval, 2.30-10.8; P < 0.001). Age > 75 years, left ventricular ejection fraction < 40%, a high maximum creatinine phosphokinase MB level, and bleeding after PCI were independently associated with persistent AKI. Persistent AKI was independently associated with worse clinical outcomes in patients who underwent emergency PCI for AMI. Advanced age, poor cardiac function, large myocardial necrosis, and bleeding were predictors of persistent AKI.; 権利情報：© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.; identifier:Scientific Reports. 2024 Mar, vol.14, no.1, article no.6299; identifier:2045-2322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4412; identifier:Scientific Reports, 14(1): 6299
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4412/1/01%e7%94%b2936%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4412/2/02%e7%94%b2936%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4412/3/03%e7%94%b2936%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1038/s41598-024-56929-y
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU