Comparison of canagliflozin and teneligliptin on energy intake and body weight in Japanese patients with Type 2 diabetes: a subanalysis of the CANTABILE study

• Material Type: 博士論文
• Title: Comparison of canagliflozin and teneligliptin on energy intake and body weight in Japanese patients with Type 2 diabetes: a subanalysis of the CANTABILE study
• Author/Editor: Isogawa, Masahiro; Makino, Hisashi; Son, Cheol; Nishimura, Kunihiro; Hirata, Takumi; Kasama, Shu; Miyamoto, Yoshihiro; Noguchi, Michio; Kasahara, Masato; Hosoda, Kiminori
• Author Heading: Isogawa, Masahiro; Makino, Hisashi; Son, Cheol; Nishimura, Kunihiro; Hirata, Takumi; Kasama, Shu; Miyamoto, Yoshihiro; Noguchi, Michio; Kasahara, Masato; Hosoda, Kiminori
• Publication, Distribution, etc.: BioMed Central
• Publication Date: 2024-08
• Publication Date (W3CDTF): 2024-08
• Alternative Title: 日本人2型糖尿病患者におけるエネルギー摂取量と体重に対するカナグリフロジンとテネリグリプチンの比較：CANTABILE試験のサブ解析
• Periodical title: Bmc Endocrine Disorders
• No. or year of volume/issue: 24 1
• Volume: 24
• Issue: 1
• Pages: 153-
• ISSN (Periodical Title): ISSN : 1472-6823
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2024-12-26
• Dissertation Number: 甲第944号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Body weight; Dipeptidyl peptidase-4 inhibitor; Energy intake; Sodium-glucose co-transporter 2 inhibitor; Type 2 diabetes
• Target Audience: 一般
• Note (General): type:Thesis; Background: While the Sodium-glucose co-transporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP4) are widely used for the glycemic control in type 2 diabetes mellitus, the differences in the effects of SGLT2 inhibitors and DPP4 inhibitors on energy intake and diabetes-related indicators are unclear. Methods: This was a subanalysis of the CANTABILE study which compared the effects of canagliflozin and teneligliptin on metabolic factors in Japanese patients with Type 2 diabetes. The changes at 24 weeks from the baseline of the diabetes-related indicators including Hemoglobin A1c (HbA1c), energy intake and body weight were compared between the canagliflozin and teneligliptin groups. Results: Seventy-five patients in the canagliflozin group and 70 patients in the teneligliptin group were analyzed. A significant decrease in HbA1c was observed in both groups. In the teneligliptin group, although energy intake was significantly reduced, there was no significant change in body weight. Conversely, in the canagliflozin group, although energy intake tended to increase, body weight significantly decreased. Conclusion: Canagliflozin and teneligliptin have different effects on the dietary status of patients with Type 2 diabetes. Our result suggests that canagliflozin can manage blood glucose without weight gain, even with increased energy intake.; 権利情報：© The Author(s) 2024. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.; identifier:Bmc Endocrine Disorders. 2024 Aug, vol.24, no.1, article no.153; identifier:1472-6823; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4420; identifier:Bmc Endocrine Disorders, 24(1): 153
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4420/1/01%e7%94%b2944%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4420/2/02%e7%94%b2944%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4420/3/03%e7%94%b2944%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1186/s12902-024-01690-6
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU