Molecular epidemiology and clinical characteristics of Staphylococcus aureus bacteremia in Japanese adults

• Material Type: 博士論文
• Title: Molecular epidemiology and clinical characteristics of Staphylococcus aureus bacteremia in Japanese adults
• Author/Editor: Tsubaki, Kohsuke; Kasahara, Kei; Asada, Tomoko; Nakano, Ryuichi; Nakano, Akiyo; Mikasa, Keiichi; Kawaguchi, Masahiko; Yano, Hisakazu
• Author Heading: Tsubaki, Kohsuke; Kasahara, Kei; Asada, Tomoko; Nakano, Ryuichi; Nakano, Akiyo; Mikasa, Keiichi; Kawaguchi, Masahiko; Yano, Hisakazu
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2025-02
• Publication Date (W3CDTF): 2025-02
• Alternative Title: 日本人成人における黄色ブドウ球菌菌血症の分子疫学と臨床的特徴
• Periodical title: Journal of infection and chemotherapy
• No. or year of volume/issue: 31 2
• Volume: 31
• Issue: 2
• Pages: 102555-
• ISSN (Periodical Title): ISSN : 1437-7780
• Degree Grantor: 奈良県立医科大学
• Date Granted: 2025-03-14
• Dissertation Number: 甲第950号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Methicillin-resistant Staphylococcus aureus; Methicillin-susceptible Staphylococcus aureus; Staphylococcus aureus bacteremia; Sequence type; Molecular epidemiology
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; type:Thesis; Introduction: Staphylococcus aureus bacteremia (SAB), especially when caused by methicillin-resistant S. aureus (MRSA), is of considerable clinical importance. In recent years, the proportion of MRSA among S. aureus has decreased, and a relative increase in the proportion of methicillin-susceptible S. aureus (MSSA) has been observed. It is therefore necessary to consider both MRSA and MSSA when assessing the microbiological and clinical significance of SAB. Materials and methods: We included SAB cases from the Nara Medical University Hospital between January 2015 and February 2017. We performed drug susceptibility testing, toxicity gene analysis, multilocus sequence typing (MLST), and polymerase chain reaction-based open reading frame typing (POT) of stored strains to integrate clinical and bacteriological characteristics. Results: There were 90 cases during the experimental period (42 MRSA and 48 MSSA), with 30-day mortality rates of 19 % for MRSA and 10.4 % for MSSA. Deaths were more frequently complicated by septic shock and disseminated intravascular coagulation. MLST studies showed that ST8, ST764, ST1, and ST15 were prevalent in the MRSA group, whereas ST5, ST188, and ST12 were prevalent in MSSA. Infective endocarditis cases had a long time from onset to the initiation of effective antimicrobials and were all MSSA. MLST and POT results correlated well, and POT appeared to have better discriminatory power. Conclusions: The severity and mortality of SAB, along with the microbiological characteristics of causative iso lates, vary by location and time. Continued studies integrating clinical and microbiological investigations are thus needed clinical and microbiological investigations are thus needed.; 権利情報：© 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.; identifier:Journal of infection and chemotherapy. 2025 Feb, vol.31, No.2, article no.102555; identifier:1437-7780; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4445; identifier:Journal of infection and chemotherapy, 31(2): 102555
• Source: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4445/1/02%e7%94%b2950%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4445/2/03%e7%94%b2950%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• Access Restrictions: インターネット公開
• Related Material (DOI): 10.1016/j.jiac.2024.11.005; https://doi.org/10.1016/j.jiac.2024.11.005
• Periodical Title (NCID): AA11627318; https://ci.nii.ac.jp/ncid/AA11627318
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU