Analysis of fracture healing process by HR-pQCT in patients with distal radius fracture

• Material Type: 博士論文
• Title: Analysis of fracture healing process by HR-pQCT in patients with distal radius fracture
• Author/Editor: 西野, 雄一朗
• Author Heading: 西野, 雄一朗
• Publication, Distribution, etc.: Springer Japan
• Publication Date: 2020-09-02
• Publication Date (W3CDTF): 2020-09-02
• Alternative Title: HR-pQCTによる橈骨遠位端骨折の治癒過程の解析
• Periodical title: Journal of Bone and Mineral Metabolism
• No. or year of volume/issue: 38 5
• Volume: 38
• Issue: 5
• Pages: 710-717
• ISSN (Periodical Title): ISSN : 0914-8779; ISSN : 1435-5604
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2020-09-02
• Dissertation Number: 甲医歯薬第1271号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Fracture healing; High-resolution peripheral quantitative computed tomography (HR-pQCT); Distal radius fracture
• Target Audience: 一般
• Note (General): Introduction: High-resolution peripheral quantitative computed tomography (HR-pQCT) has enabled us to observe the changes in bone microarchitecture over time in vivo. In this study, the process of fracture healing was analyzed using HR-pQCT in patients with distal radius fracture who underwent osteosynthesis. Materials and methods: A total of 10 fracture sites identified from four patients with a distal radius fracture who underwent internal fixation with a volar locking plate (mean age 68.8 years, all women) were investigated. HR-pQCT was performed within a week (baseline) 4, 12, and 24 weeks after fracture. Rectangular region of interest (ROI) was established in the fracture site, inner callus, and external callus area, and the changes in bone mineral density (BMD) in each region were analyzed. Results: From baseline to 24 weeks post-fracture, the BMD changed from 105.5 (95% CI 98.6?113) to 428.0 (331?554) mgHA/ccm at the fracture site, from 111.0 (104?119) to 375.3 (290?486) mgHA/ccm at the inner callus area, and from 98.5 (91.6?106) to 171.6 (132?222) mgHA/ccm at the external callus area. The BMD increased at the fracture site and inner callus area, but increased only slightly at the external callus area. At 24 weeks post-fracture, the BMD at the fracture site and inner callus area was significantly higher than the external callus area. Conclusion In the healing process of postoperative distal radius fractures, increased BMD at the inner surface of the fracture site was confirmed in all fractures. Bone formation on the endosteal side may be a necessary condition for bone union of distal radius fractures.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1271号 学位授与年月日:令和2年9月2日; Author: Yuichiro Nishino, Ko Chiba, Makoto Era, Narihiro Okazaki, Takashi Miyamoto, Akihiko Yonekura, Masato Tomita & Makoto Osaki; Citation: Journal of Bone and Mineral Metabolism, 38(5), pp.710-717; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
• Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=51&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=51&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): c The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020. This is a post-peer-review, pre-copyedit version of an article published in Journal of Bone and Mineral Metabolism. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00774-020-01109-x.
• Related Material: http://hdl.handle.net/10069/40341
• Related Material (DOI): 10.1007/s00774-020-01109-x
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ